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Preemptive analgesia for postoperative hysterectomy pain control: systematic review and clinical practice guidelines.

Abstract：

OBJECTIVE:The objective of the study was to investigate the effectiveness of preemptive analgesia at pain control in women undergoing total abdominal hysterectomy. DATA SOURCES:Eligible studies, published through May 31, 2016, were retrieved through Medline, Cochrane Central Register for Controlled Trials, and Cochrane Database of Systematic Reviews. STUDY ELIGIBILITY:We included randomized controlled trials with the primary outcome of pain control in women receiving a preemptive medication prior to total abdominal hysterectomy. Comparators were placebo, different doses of the same medication as intervention, or other nonnarcotic or narcotic medication. STUDY APPRAISAL AND SYNTHESIS METHODS:Study data were extracted by one reviewer and confirmed by a second reviewer. For each outcome we graded the quality of the evidence. Studies were classified by the type of medication used and by outcome type. RESULTS:Eighty-four trials met eligibility, with 69 included. Among nonnarcotic medications, paracetamol, gabapentin, and rofecoxib combined with gabapentin resulted in improvements in pain assessment compared with placebo and other nonnarcotic medications. Patient satisfaction was higher in patients who were given gabapentin combined with paracetamol compared with gabapentin alone. Use of preemptive paracetamol, gabapentin, bupivacaine, and phenothiazine resulted in less narcotic usage than placebo. All narcotics (ketamine, morphine, fentanyl) resulted in improved pain control compared with placebo. Narcotics had a greater reduction in pain assessment scores compared with nonnarcotics, and their use resulted in lower total narcotic usage. CONCLUSION:Preemptive nonnarcotic and narcotic medications prior to abdominal hysterectomy decrease total narcotic requirements and improve patient postoperative pain assessment and satisfaction scores.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Steinberg AC,Schimpf MO,White AB,Mathews C,Ellington DR,Jeppson P,Crisp C,Aschkenazi SO,Mamik MM,Balk EM,Murphy M

doi

10.1016/j.ajog.2017.03.013

subject

Has Abstract

pub_date

2017-09-01 00:00:00

pages

303-313.e6

issue

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(17)30424-6

journal_volume

217

pub_type

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Preemptive analgesia for postoperative hysterectomy pain control: systematic review and clinical practice guidelines.