当前位置： SCI文献检索 > AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY期刊下所有文献 > Cellular response to chemotherapy and radiation in cervical cancer.

Cellular response to chemotherapy and radiation in cervical cancer.

Abstract：

:Effect of irradiation alone and irradiation after 5-fluorouracil (5-FU), paclitaxel, or cisplatin (CDDP) was investigated in human cervical cell lines (CaSki, ME180, SiHa, and C33A). High-risk human papillomavirus (HPV) (+) CaSki and SiHa cells were the most resistant to CDDP, 5-FU, and radiation treatments. Radiation and CDDP and 5-FU resulted in decreased survival of HPV 16 and 18 (+) cells, whereas addition of paclitaxel to radiation treatments decreased killing. Enhanced killing of ME180 cells containing HPV39 sequences was demonstrated with chemoradiotherapy with all agents. HPV(-) C33A was more sensitive to radiation than the other cell lines, and the addition of chemotherapeutic agents did not result in significant change in cytotoxicity. Expression of survivin was inversely proportional to cell sensitivity to CDDP, 5-FU, and radiation. Constitutive AKT levels are the lowest in cell lines that are the most resistant to CDDP, 5-FU, and radiation. These data provide correlation of response to combined therapeutic modalities with HPV status of cervical cancer and expression of survivin and AKT.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Saxena A,Yashar C,Taylor DD,Gercel-Taylor C

doi

10.1016/j.ajog.2004.12.045

subject

Has Abstract

pub_date

2005-05-01 00:00:00

pages

1399-403

issue

5

eissn

0002-9378

issn

1097-6868

pii

S0002937805000190

journal_volume

192

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY文献大全
  • Adhesions after extensive gynecologic surgery: clinical significance, etiology, and prevention.

    abstract：:Postoperative adhesions occur in 60% to 90% of patients undergoing major gynecologic surgery and represent one of the most common causes of intestinal obstruction in the industrialized world. The incidence of adhesion-related intestinal obstruction after gynecologic surgery for benign conditions without hysterectomy i...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/s0002-9378(94)70170-9

    authors： Monk BJ,Berman ML,Montz FJ

    更新日期：1994-05-01 00:00:00

  • Maternal serum alpha-fetoprotein screening: further consideration of low-volume testing.

    abstract：:Unrecognized assay drift that may occur during low-volume (fewer than 500 specimens per week) maternal serum alpha-fetoprotein testing could result in either underestimation or overestimation of the number of pregnant women who are at increased risk of fetal malformations and genetic anomalies. Quality control softwar...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(91)90502-i

    authors： Strickland DM,Butzin CA,Wians FH Jr

    更新日期：1991-03-01 00:00:00

  • Condom use and incident sexually transmitted infection after initiation of long-acting reversible contraception.

    abstract：BACKGROUND:Use of more effective contraception may lead to less condom use and increased incidence of sexually transmitted infection. OBJECTIVE:The objective of this study was to compare changes in condom use and incidence of sexually transmitted infection acquisition among new initiators of long-acting reversible con...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2017.09.009

    authors： McNicholas CP,Klugman JB,Zhao Q,Peipert JF

    更新日期：2017-12-01 00:00:00

  • The prevention of postoperative pelvic adhesions: an animal study comparing barrier methods with dextran 70.

    abstract：:There are two major approaches to the prophylaxis for adhesions: chemical methods (e.g., dextran) and barrier methods. Theoretically, dextran prevents the formation of adhesions by a surface-coating or hydroflotation effect, whereas the barrier methods either prevent the formation of or mask adhesions by covering and ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(82)90018-7

    authors： Soules MR,Dennis L,Bosarge A,Moore DE

    更新日期：1982-08-01 00:00:00

  • Perinatal HIV testing and diagnosis in Illinois after implementation of the Perinatal Rapid Testing Initiative.

    abstract：OBJECTIVE:The objective of the study was to assess whether implementation of a statewide initiative was associated with changes in perinatal human immunodeficiency virus (HIV) testing practices. STUDY DESIGN:This was an observational cohort study of all 1,141,799 women who delivered in Illinois birthing hospitals over...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2012.08.006

    authors： Wong AE,Garcia PM,Olszewski Y,Statton A,Bryant Borders A,Grobman WA,Cohen MH

    更新日期：2012-11-01 00:00:00

  • Screening for preeclampsia using first-trimester serum markers and uterine artery Doppler in nulliparous women.

    abstract：OBJECTIVE:To evaluate the screening accuracy of pregnancy hypertensive disorders by maternal serum biomarkers and uterine artery Doppler in the first trimester. STUDY DESIGN:Prospectively enrolled nulliparous women had uterine artery Doppler and serum measured at 11-13 weeks. Maternal characteristics, uterine artery D...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2010.06.014

    authors： Audibert F,Boucoiran I,An N,Aleksandrov N,Delvin E,Bujold E,Rey E

    更新日期：2010-10-01 00:00:00

  • Evidence for a partial deletion in the androgen receptor gene in a phenotypic male with azoospermia.

    abstract：:Androgen resistance is thought to vary phenotypically from a normal female to an infertile male. Previous evaluation of infertile males has been limited to androgen receptor-binding affinity. The androgen receptor gene has been isolated, cloned, and studied extensively in patients with complete androgen insensitivity ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(91)90052-s

    authors： Akin JW,Behzadian A,Tho SP,McDonough PG

    更新日期：1991-12-01 00:00:00

  • Correlation between amniotic fluid glucose concentration and amniotic fluid volume in pregnancy complicated by diabetes.

    abstract：OBJECTIVE:Pregnancies complicated by diabetes are frequently characterized by an increased volume of amniotic fluid, and the pathophysiologic mechanism of this increase is not known. Our goal was to evaluate the relationship between amniotic fluid glucose concentration and the amniotic fluid index in pregnancies compli...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(00)70343-7

    authors： Dashe JS,Nathan L,McIntire DD,Leveno KJ

    更新日期：2000-04-01 00:00:00

  • Objective structured assessment of technical skills for repair of fourth-degree perineal lacerations.

    abstract：OBJECTIVE:The objective of this study was to assess the reliability and validity of an objective structured assessment of technical skills (OSATS) for repair of fourth-degree obstetric lacerations on a surgical model. STUDY DESIGN:Three blinded judges reviewed recordings of 20 junior and 20 senior obstetrics-gynecolog...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2008.07.054

    authors： Siddiqui NY,Stepp KJ,Lasch SJ,Mangel JM,Wu JM

    更新日期：2008-12-01 00:00:00

  • Squamous cell carcinoma of the vagina following hysterectomy.

    abstract：:A retrospective analysis of 29 cases of squamous cell neoplasia of the vagina following hysterectomy is presented. Two groups of patients were identified; the first presented following hysterectomy for cervical dysplasia or neoplasia on an average of 5.7 years later, and the second presented following hysterectomy for...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(81)90016-8

    authors： Stuart GC,Allen HH,Anderson RJ

    更新日期：1981-02-01 00:00:00

  • Who returns for postpartum glucose screening following gestational diabetes mellitus?

    abstract：OBJECTIVE:The objective of the study was to determine the prevalence of postpartum impaired glucose regulation (IGR) and factors associated with glucose screening following gestational diabetes mellitus (GDM). STUDY DESIGN:This was a prospective cohort study of 707 women with GDM who delivered at the University Hospit...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2007.09.015

    authors： Hunt KJ,Conway DL

    更新日期：2008-04-01 00:00:00

  • Mid-trimester abortion induced by intravaginal administration of prostaglandin E2 suppositories.

    abstract：:Mid-trimester abortion was successfully induced in 70 of 71 patients by administration of vaginal PGE2 suppositories. The one patient who failed to abort with this method was pregnant in the blind horn of a duplex uterus. The mean abortion time for the successful inductions was 11.88 hours. Multiparous patients aborte...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(75)90353-1

    authors： Lauersen NH,Secher NJ,Wilson KH

    更新日期：1975-08-15 00:00:00

  • A simple estimated fetal weight equation based on real-time ultrasound measurements of fetuses less than thirty-four weeks' gestation.

    abstract：:Based on ultrasonographic mensuration, a number of equations have previously been devised for the purpose of estimating fetal weights. The objective of this study was to develop a mathematical equation that is simple, accurate, and easy to use when applied to preterm or low-birth weight fetuses (less than 2,500 gm). R...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(83)91195-x

    authors： Thurnau GR,Tamura RK,Sabbagha R,Depp OR 3rd,Dyer A,Larkin R,Lee T,Laughlin C

    更新日期：1983-03-01 00:00:00

  • The temporal efficacy of early second-look lysis of adhesions in reducing postoperative adhesions in a murine model.

    abstract：OBJECTIVE:Our aim was to determine whether early second-look lysis of adhesions reduces postoperative adhesions. STUDY DESIGN:With the murine uterine horn model, early second-look lysis of adhesions was performed 5, 7, 14, and 21 days after an electrocautery injury. Sites with adhesions (between 36 and 46/time point) ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(98)70366-7

    authors： Haney AF,Doty E

    更新日期：1998-08-01 00:00:00

  • Functional significance of the zonal morphologic differences in the normal human placenta. A morphometric study.

    abstract：:Previous investigations have shown that the human placenta is a complex organ with different zones, each with a unique morphology. These zonal morphologic difference have been related to a probable blood PO2 gradient operating in the intervillous space. This study describes zonal variations in the vertical plane of th...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(78)90007-8

    authors： Teasdale F

    更新日期：1978-04-01 00:00:00

  • The experience with vaginal birth after cesarean delivery in a small rural community practice.

    abstract：OBJECTIVE:The purpose of this study was to determine if the success and safety of vaginal birth after cesarean delivery in a small, isolated, rural hospital compare with those seen in larger centers. STUDY DESIGN:As part of a continuing study, the prenatal and hospital records of all patients with previous cesarean de...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(12)90885-6

    authors： Raynor BD

    更新日期：1993-01-01 00:00:00

  • Cocaine alters placental production of thromboxane and prostacyclin.

    abstract：OBJECTIVE:The objective of this study was to test the hypothesis that cocaine alters placental prostaglandin production in vitro. STUDY DESIGN:Placentas were obtained from healthy women (n = 6) after normal vaginal delivery at term. Placental explants (300 mg) were incubated in duplicate at 37 degrees C in the presenc...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(94)90015-9

    authors： Monga M,Chmielowiec S,Andres RL,Troyer LR,Parisi VM

    更新日期：1994-10-01 00:00:00

  • Exercise in pregnancy. II. Fetal responses.

    abstract：:Healthy pregnant women underwent a mild exercise study to evaluate the effects of this amount of work on their fetuses. The results indicated that there were no direct correlations between exercise and fetal body or breathing movements at this particular work intensity (2.33 m). We found a relationship between the mat...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(83)90003-0

    authors： Platt LD,Artal R,Semel J,Sipos L,Kammula RK

    更新日期：1983-11-01 00:00:00

  • Effect of uterine contractility and maternal hypotension on prolonged decelerations after bupivacaine epidural anesthesia.

    abstract：:Patients with prolonged decelerations after bupivacaine epidural anesthesia were matched with control patients. It was found that there were no differences in the decrease in mean arterial blood pressure after epidural anesthesia between those with prolonged decelerations (5 +/- 9 mm Hg) and those without (5 +/- 9 mm ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(90)91073-l

    authors： Steiger RM,Nageotte MP

    更新日期：1990-09-01 00:00:00

  • Antenatal vitamin K therapy of the low-birth-weight infant.

    abstract：OBJECTIVE:The purpose of our study was to determine whether maternal vitamin K1 administered antenatally improved global coagulation parameters and the levels of specific vitamin K-dependent proteins in low-birth-weight infants. STUDY DESIGN:Thirty-three preterm mothers admitted in labor were assigned in a prospective...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0002-9378(94)70389-2

    authors： Dickson RC,Stubbs TM,Lazarchick J

    更新日期：1994-01-01 00:00:00

  • Congenital heart defects after maternal fever.

    abstract：OBJECTIVE:The purpose of this study was to evaluate whether maternal febrile illnesses in early pregnancy are associated with increased risk for congenital heart defects in the offspring and whether such risk is mitigated by multivitamin supplement use. STUDY DESIGN:From a multistate population-based case-control stud...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2013.10.880

    authors： Botto LD,Panichello JD,Browne ML,Krikov S,Feldkamp ML,Lammer E,Shaw GM,National Birth Defects Prevention Study.

    更新日期：2014-04-01 00:00:00

  • The fetal inflammatory response syndrome is a risk factor for morbidity in preterm neonates.

    abstract：OBJECTIVE:The aim of this study was to show and discuss an association between fetal inflammatory response syndrome (FIRS) and an adverse neonatal outcome defined as combined severe neonatal morbidity and mortality in preterm neonates hospitalized in our neonatal intensive care unit. STUDY DESIGN:This was an observati...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2013.08.030

    authors： Hofer N,Kothari R,Morris N,Müller W,Resch B

    更新日期：2013-12-01 00:00:00

  • Conservative treatment of ectopic pregnancy with methotrexate.

    abstract：:Six subjects with distal ampullary ectopic pregnancies were treated with four doses of intravenous methotrexate (1.0 mg/kg) followed by four doses of leucovorin (0.1 mg/kg, intramuscularly). The diagnosis was established in all cases by laparoscopy following sonography and radioimmunoassay for serum beta subunit of hu...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(86)90716-7

    authors： Ory SJ,Villanueva AL,Sand PK,Tamura RK

    更新日期：1986-06-01 00:00:00

  • Differential symptom response to parenteral estrogen and/or androgen administration in the surgical menopause.

    abstract：:The investigation of estrogen and/or androgen administration on physical and psychological symptoms in the surgical menopause was carried out in a prospective, double-blind, crossover design. When patients who received either a combined estrogen-androgen drug or androgen alone were compared with those who received est...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-9378(85)90001-8

    authors： Sherwin BB,Gelfand MM

    更新日期：1985-01-15 00:00:00

  • Isoxsuprine-induced release of pulmonary surfactant in the rabbit fetus.

    abstract：:Rabbit fetuses were injected intramuscularly with 0.5 mg. of isoxsuprine on the twenty-eighth day of gestation. They were killed in utero four hours after the injection, and fetal pulmonary fluid (FPF) was collected through a tracheal catheter. The quantity of FPF and the lung weight/body weight ratio were both signif...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(77)90744-x

    authors： Enhorning G,Chamberlain D,Contreras C,Burgoyne R,Robertson B

    更新日期：1977-09-15 00:00:00

  • Epidemiology of low-grade serous ovarian cancer.

    abstract：OBJECTIVE:The objective of the study was to determine whether the epidemiology of low-grade ovarian serous cancers is distinct from that of high-grade ovarian serous cancers. STUDY DESIGN:The National Cancer Institute's Surveillance Epidemiology and End Results (SEER) program reports incidence, and survival, data from...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2008.01.035

    authors： Plaxe SC

    更新日期：2008-04-01 00:00:00

  • Oral contraceptives and platelet aggregation.

    abstract：:There are conflicting data in the literature concerning the effects of oral contraceptives on platelet aggregation. We studied 26 healthy women who used oral contraceptives for at least three months. The control group consisted of 25 healthy women of childbearing age, who were receiving no medications. No differences ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(78)90897-9

    authors： Shevde N,Sussman II,Rosner F,Pacholuk V

    更新日期：1978-10-01 00:00:00

  • National patterns of care and fertility outcomes for reproductive-aged women with endometrial cancer or atypical hyperplasia.

    abstract：BACKGROUND:Although it is uncommon, the incidence of endometrial cancer and atypical hyperplasia among reproductive-aged women is increasing. The fertility outcomes in this population are not well described. OBJECTIVE:We aim to describe the patterns of care and fertility outcomes of reproductive-aged women with endome...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2019.05.029

    authors： Harrison RF,He W,Fu S,Zhao H,Sun CC,Suidan RS,Woodard TL,Rauh-Hain JA,Westin SN,Giordano SH,Meyer LA

    更新日期：2019-11-01 00:00:00

  • Long-term observations of cervical cancer.

    abstract：:A consecutive series of approximately 1100 patients, treated for cancer of the cervix over a span of 45 years, presents an increasingly favorable stage distribution. Emergence of exfoliative cytology as a diagnostic technique accelerates allocation of new patients to Stage I. Cumulative rates of dying from cervical ca...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(87)90063-9

    authors： Arneson AN,Kao MS

    更新日期：1987-03-01 00:00:00

  • Genomic-directed targeted therapy increases endometrial cancer cell sensitivity to doxorubicin.

    abstract：OBJECTIVE:We aimed to utilize genome-wide expression analysis to identify molecular pathways that may contribute to endometrial cancer resistance to doxorubicin (DOX) and that also represent therapeutic targets to increase DOX sensitivity. STUDY DESIGN:Ten endometrial cancer cell lines were subjected to gene expressio...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2010.02.003

    authors： Indermaur MD,Xiong Y,Kamath SG,Boren T,Hakam A,Wenham RM,Apte SM,Lancaster JM

    更新日期：2010-08-01 00:00:00