Antenatal vitamin K therapy of the low-birth-weight infant.

Abstract:

OBJECTIVE:The purpose of our study was to determine whether maternal vitamin K1 administered antenatally improved global coagulation parameters and the levels of specific vitamin K-dependent proteins in low-birth-weight infants. STUDY DESIGN:Thirty-three preterm mothers admitted in labor were assigned in a prospective, blinded fashion to receive either intramuscular vitamin K1 (17) or placebo (16). At delivery cord blood samples were tested for prothrombin time, activated partial thromboplastin time, factor II and protein C activity, and antigen levels. Statistical analysis was by Student t test. RESULTS:No statistically significant differences could be demonstrated with regard to group mean values for global tests (prothrombin time, activated partial thromboplastin time) or specific vitamin K-dependent protein levels (factor II, protein C) in newborns whose mothers received antenatal vitamin K compared with those who did not. CONCLUSION:These results would suggest that antenatal vitamin K1 therapy to mothers < 32 weeks' gestation has no significant effect on the level of vitamin K-dependent factors in the fetus.

journal_name

Am J Obstet Gynecol

authors

Dickson RC,Stubbs TM,Lazarchick J

doi

10.1016/s0002-9378(94)70389-2

subject

Has Abstract

pub_date

1994-01-01 00:00:00

pages

85-9

issue

1 Pt 1

eissn

0002-9378

issn

1097-6868

pii

S0002937894004084

journal_volume

170

pub_type

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