Prenatal paternity testing with deoxyribonucleic acid techniques.

Abstract:

OBJECTIVES:Our purpose was to determine the feasibility and optimal techniques for prenatal paternity testing. STUDY DESIGN:Since January 1989 we have offered prenatal paternity testing by deoxyribonucleic acid testing. We analyzed the ability to complete the testing and the time required to complete the testing and developed polymerase chain reaction-based tests to speed test results. RESULTS:Before April 1990 only five of nine cases could be completed. Since that time 28 consecutive cases were successfully completed before delivery. Introduction of polymerase chain reaction-based testing has allowed us to perform testing on uncultured chorionic villi and to derive results within 3 weeks. CONCLUSION:Analysis of uncultured chorionic villi allows prenatal paternity testing to be completed within the first trimester of pregnancy. Prenatal paternity testing can also be performed on cultured amniocytes and chorionic villi.

journal_name

Am J Obstet Gynecol

authors

Strom CM,Rechitsky S,Ginsberg N,Verlinsky O,Verlinsky Y

doi

10.1016/s0002-9378(96)70220-x

subject

Has Abstract

pub_date

1996-06-01 00:00:00

pages

1849-53; discussion 1853-4

issue

6

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(96)70220-X

journal_volume

174

pub_type

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