Effects of prolonged infusion of beta-adrenergic agonists on uterine and umbilical blood flow in pregnant sheep.

Abstract:

:We have extended our evaluation of the effects of three beta-adrenergic agents in near-term pregnant sheep to include a period of infusion three times longer than previously studied. This extension has provided the following information: (1) Initial depression of uterine blood flow and mean arterial pressure associated with administration of ritodrine or salbutamol abate with time despite continued drug infusion; (2) the uterine hyperemia associated with salbutamol and fenoterol are drug-related rather than postinfusion-related phenomena; (3) increased uterine vascular resistance is found with ritodrine, and decreased uterine vascular resistance occurs with salbutamol and fenoterol.

journal_name

Am J Obstet Gynecol

authors

Brennan SC,McLaughlin MK,Chez RA

doi

10.1016/0002-9378(77)90708-6

subject

Has Abstract

pub_date

1977-08-01 00:00:00

pages

709-15

issue

7

eissn

0002-9378

issn

1097-6868

pii

0002-9378(77)90708-6

journal_volume

128

pub_type

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