Cord blood lymphocyte in vitro responses to influenza A antigens after an epidemic of influenza A/Port Chalmers/73 (H3N2).

Abstract:

:Samples of cord blood from 46 deliveries were collected between 2 and 8 mo after an epidemic of influenza caused by A/Port Chalmers/73 (H3H2) virus. Of 10 samples with HAI antibody titers against A/Port Chalmers of 1:16 or greater, one had 2-mercaptoethanol-sensitive IgM class antibodies against the virus. Lymphocyte proliferative responses with the use of A/Port Chalmers antigens were increased in six of 46 samples. These results provide immunologic evidence that certain neonates have IgM antibodies and lymphocytes sensitized for influenza A virus. Our results suggest, but do not prove definitively, that influenza A/Port Chalmers virus infected the fetus prior to delivery.

journal_name

Am J Obstet Gynecol

authors

Ruben FL,Thompson DS

doi

10.1016/0002-9378(81)90609-8

subject

Has Abstract

pub_date

1981-10-15 00:00:00

pages

443-7

issue

4

eissn

0002-9378

issn

1097-6868

pii

0002-9378(81)90609-8

journal_volume

141

pub_type

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