Glucocorticoids and the rhesus fetal lung.

Abstract:

:The effects of glucocorticoids on primate fetal lung function have not been clearly delineated. In this prospective study of preterm rhesus fetuses exposed in utero to betamethasone for 72 hours, the most significant alteration was a striking increase in maximum lung volumes. Functionally less significant increases in residual lung volumes were also noted. The lungs of the treated fetuses did not exhibit lower extract surface tensions or increased phospholipid concentrations. These findings suggest that the major effect of betamethasone is on lung connective tissue elements, with minimal effects on alveolar surfactant. Additional evidence of the multisystemic effects of glucocorticoids was obtained in that significant differences in fetal, adrenal, hepatic, and placental weights also were observed.

journal_name

Am J Obstet Gynecol

authors

Johnson JW,Mitzner W,London WT,Palmer AE,Scott R,Kearney K

doi

10.1016/0002-9378(78)90267-3

subject

Has Abstract

pub_date

1978-04-15 00:00:00

pages

905-16

issue

8

eissn

0002-9378

issn

1097-6868

pii

0002-9378(78)90267-3

journal_volume

130

pub_type

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