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Perinatal risk indicators for long-term neurological morbidity among preterm neonates.

Abstract：

OBJECTIVE:Many obstetric interventions are performed to improve long-term neonatal outcome. However, long-term neonatal outcome is usually not a primary outcome because it is time-consuming and expensive. The aim of this project was to identify different perinatal risk indicators and to develop prediction models for neurologic morbidity at 2 and 5 years of age. STUDY DESIGN:Data from a Dutch cohort study of preterm and small-for-gestational-age infants was used. Neonates who were born in The Netherlands in 1983 with a gestational age of <34 weeks and without congenital abnormalities were included (n = 753). Infants were divided in 3 groups: no handicap, minor handicap, and major handicap. RESULTS:Common risk indicators for major handicaps at 2 and 5 years of age were male sex (odds ratio, 2.7 and 3.0, respectively), seizures after ≥2 days of life (odds ratio, 5.8 and 5.8, respectively), and intracranial hemorrhage (odds ratio, 3.8 and 2.6, respectively). CONCLUSION:In this cohort, male sex, intracranial hemorrhage, and seizures seem to be important risk indicators for long-term neurologic morbidity.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Teune MJ,van Wassenaer AG,van Dommelen P,Mol BW,Opmeer BC,Dutch POPS-19 Collaborative Study Group.

doi

10.1016/j.ajog.2011.02.055

subject

Has Abstract

pub_date

2011-05-01 00:00:00

pages

396.e1-396.e14

issue

5

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(11)00245-6

journal_volume

204

pub_type

杂志文章

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