当前位置： SCI文献检索 > AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY期刊下所有文献 > First-trimester nuchal translucency, nasal bones, and trisomy 21 in selected and unselected populations.

First-trimester nuchal translucency, nasal bones, and trisomy 21 in selected and unselected populations.

Abstract：

OBJECTIVE:The purpose of this study was to assess the role of fetal nasal bones evaluation in first-trimester screening for trisomy 21 in selected and unselected pregnancies. STUDY DESIGN:Visualization of the nasal bones was attempted in women attending for routine nuchal translucency screening (unselected population, n = 7116, 12 cases of trisomy 21), as well as in high-risk pregnancies referred to our tertiary care center (selected population, n = 510, 23 cases of trisomy 21). RESULTS:The sensitivity, specificity, positive and negative predictive value of absent nasal bones for trisomy 21 were 16.7%, 97.3%, 1.1%, 99.8% and 47.6%, 95.3%, 33.3%, 97.4% in the unselected and selected population, respectively. At logistic regression analysis including nuchal translucency and nasal bones findings, the latter resulted to be an independent predictor of trisomy 21 in the selected but not in the unselected population. CONCLUSION:First-trimester nasal bones assessment for trisomy 21 screening has a very different performance in selected and unselected pregnancies.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Prefumo F,Sairam S,Bhide A,Thilaganathan B

doi

10.1016/j.ajog.2005.09.008

subject

Has Abstract

pub_date

2006-03-01 00:00:00

pages

828-33

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(05)01464-X

journal_volume

194

pub_type

杂志文章

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