A practical approach to the diagnosis of polycystic ovary syndrome.

Abstract:

:The diagnosis of polycystic ovary syndrome (PCOS) is primarily achieved through clinical history and physical findings. The principle features are hirsutism or biochemical evidence of excess androgen production and irregular menstrual bleeding caused by the chronic anovulation. Associated findings include insulin resistance with compensatory hyperinsulinemia and obesity. Ultrasound imaging of the ovary has facilitated the diagnosis. It is important to exclude conditions that may mimic PCOS, such as hyperthecosis, congenital adrenal hyperplasia, 21-hydroxylase deficiency, Cushing's syndrome, and androgen-producing neoplasms. These disorders are usually revealed by appropriate laboratory assessment. Screening tests include measurement of serum total testosterone, DHEA sulfate, and 17-hydroxyprogesterone. In addition, in the obese individual, determinations of glucose and insulin levels, as well as a lipid profile, are highly recommended.

journal_name

Am J Obstet Gynecol

authors

Chang RJ

doi

10.1016/j.ajog.2004.04.045

subject

Has Abstract

pub_date

2004-09-01 00:00:00

pages

713-7

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002937804004648

journal_volume

191

pub_type

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