Spontaneous closure of the human fetal ductus arteriosus--A cause of fetal congestive heart failure.

Abstract:

OBJECTIVE:Closure of the fetal ductus arteriosus, which is usually due to nonsteroidal antiinflammatory agents, may be detrimental. Therefore prenatal and postnatal clinical and echocardiographic findings in four human fetuses with spontaneous ductus arteriosus occlusion are reported. STUDY DESIGN:Echocardiographic and clinical data were retrospectively analyzed. RESULTS:Spontaneous closure of the ductus arterious was discovered in four fetuses (gestational age 34 to 38 weeks). No mother had received nonsteroidal antiinflammatory agents. Enlargement of the right heart and pulmonary arteries and tricuspid and pulmonary regurgitation were present in all cases. Two fetuses had right ventricular hypertension. Postnatally their right ventricular function recovered promptly. The others had severe right heart failure with abnormal umbilical venous pulsations. After immediate delivery none had signs of persistent pulmonary hypertension. However, they have echocardiographic evidence of right ventricular dysfunction 2 to 6 months after delivery. CONCLUSIONS:Occlusion of the fetal ductus arteriosus may also occur in the absence of treatment with nonsteroidal antiinflammatory agents. Immediate delivery resulted in good clinical outcome, although right ventricular dysfunction may persist.

journal_name

Am J Obstet Gynecol

authors

Hofstadler G,Tulzer G,Altmann R,Schmitt K,Danford D,Huhta JC

doi

10.1016/s0002-9378(96)70317-4

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

879-83

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(96)70317-4

journal_volume

174

pub_type

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