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Inhibition of uterine contractility with various tocolytics with and without progesterone: in vitro studies.

Abstract：

OBJECTIVE:Various tocolytics are used to suppress uterine contractility in patients in preterm labor. Progesterone (P4) is used in patients at high risk for preterm delivery. In this study, we evaluated the effects of various tocolytics with and without P4 to examine effects on uterine contractility. STUDY DESIGN:Uterine tissues (n = 280) from women undergoing cesarean at term were exposed in vitro to various agents (vehicle, magnesium sulfate [MgSO(4)], nifedipine, indomethacin, or pinacidil-all with and without P4). Contractility was measured before and after addition of the various agents. RESULTS:P4 alone at 10(-5) mol/L concentration has little effect to inhibit contractility (P ≥ .05). MgSO(4) (2-8 × 10(-3) mol/L) inhibits uterine contractility (P < .05) but there is no change when combined with P4 (P > .05). Nifedipine (10(-8) mol/L) and indomethacin (10(-5) mol/L) inhibit contractions alone (P < .05) and to a greater extent when combined with P4 (P < .05). P4 significantly (P < .05) reduced the effects of pinacidil (10(-6.5) mol/L). CONCLUSION:Combinations of P4 with nifedipine or indomethacin, but not MgSO(4), might be used to effectively suppress preterm labor.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Baumbach J,Shi SQ,Shi L,Balducci J,Coonrod DV,Garfield RE

doi

10.1016/j.ajog.2011.12.011

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

254.e1-5

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(11)02409-4

journal_volume

206

pub_type

杂志文章

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