Elevated maternal plasma corticotropin-releasing hormone levels in pregnancies complicated by preterm labor.

Abstract:

OBJECTIVES:We investigated whether maternal plasma levels of the placental hormone corticotropin-releasing hormone are elevated in pregnancies complicated by preterm labor. STUDY DESIGN:Mean maternal corticotropin-releasing hormone levels were studied in women who met specific criteria for preterm labor and in women with normal pregnancies. Levels were also compared in the latent and active phases during term labor. RESULTS:In pregnancies complicated by preterm labor, maternal corticotropin-releasing hormone levels were higher than in normal pregnancies; this elevation occurred before labor was diagnosed clinically (p less than 0.05). When preterm labor was associated with infection, the mean levels were not elevated. Mean plasma levels were similar in latent and active phases during labor at term. CONCLUSION:Maternal plasma corticotropin-releasing hormone levels are elevated in association with preterm labor. This elevation does not appear to be due to labor itself and may reflect an early activation of the placenta before the onset of preterm labor.

journal_name

Am J Obstet Gynecol

authors

Warren WB,Patrick SL,Goland RS

doi

10.1016/s0002-9378(11)90606-1

subject

Has Abstract

pub_date

1992-04-01 00:00:00

pages

1198-204; discussion 1204-7

issue

4

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(11)90606-1

journal_volume

166

pub_type

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