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Lycopene and other carotenoid intake in relation to risk of uterine leiomyomata.

Abstract：

OBJECTIVE:Carotenoids have antioxidant properties and have been associated with reduced risks of some cancers. We hypothesized that carotenoid intake may reduce the risk of diagnosed uterine leiomyoma (UL). STUDY DESIGN:We evaluated the associations between dietary carotenoids and risk of diagnosed UL in 82,512 premenopausal women aged 26-46 years in 1991 in the Nurses' Health Study II over 10 years of follow-up. Diet was assessed every 4 years with a validated food frequency questionnaire, and incidence of UL was assessed biennially by questionnaire. RESULTS:Total lycopene intake was not associated with diagnosed UL risk. Intake of beta-carotene was associated with slightly increased risks of diagnosed UL; this association was restricted to current smokers (for highest vs lowest quintile, relative risk = 1.36, 95% confidence interval 1.05 to 1.76; P(trend) = .003). CONCLUSION:Overall, our findings do not suggest that carotenoids reduce the risk of diagnosed UL. Among current smokers, high intake of beta-carotene may slightly increase risk of diagnosed UL.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Terry KL,Missmer SA,Hankinson SE,Willett WC,De Vivo I

doi

10.1016/j.ajog.2007.05.033

subject

Has Abstract

pub_date

2008-01-01 00:00:00

pages

37.e1-8

issue

1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(07)00677-1

journal_volume

198

pub_type

杂志文章

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