The efficacy and acceptability of intravenously administered prostaglandin F as an abortifacient.

Abstract:

:The efficacy and acceptability of PGF2alpha (prostaglandin F2alpha) as an abortifacient has been examined during intravenous infusion in 15 obstetrically normal midtrimester patients. Infusions of up to 200 mcg/minute of PGF2alpha induced complete abortions in 3 and incomplete abortions in an additional 3 patients. 4 patients failed to abort. All patients experienced undesirable side effects, i.e., nausea, vomiting, and diarrhea, in various degrees. This form of therapy cannot be recommended for routine therapeutic use; however, current clinical studies complemented by model experiments in animals suggest that the efficacy and acceptability of PGF2alpha can be increased by topical, intrauterine administration. Preliminary deductions pertinent to the mechanism of the abortifacient effect of PGF2alpha have been made based on measurements of intraamniotic pressure, circulating estradiol-17 beta, and progesterone levels.

journal_name

Am J Obstet Gynecol

authors

Csapo AI,Sauvage JP,Wiest WG

doi

10.1016/0002-9378(71)90104-9

subject

Has Abstract

pub_date

1971-12-15 00:00:00

pages

1059-63

issue

8

eissn

0002-9378

issn

1097-6868

pii

0002-9378(71)90104-9

journal_volume

111

pub_type

杂志文章
  • Comparative cervical microflora shifts after cefoxitin or cefazolin prophylaxis against infection following cesarean section.

    abstract::The aerobic and anaerobic cervical microflora was determined before operation and on day 4 after operation in groups of women undergoing a clinical trial of prophylaxis with three doses of cefoxitin, cefazolin, or placebo for infectious complications of nonelective cesarean section. Floral shifts occurred post partum,...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章

    doi:10.1016/0002-9378(84)90109-1

    authors: Stiver HG,Forward KR,Tyrrell DL,Krip G,Livingstone RA,Fugere P,Lemay M,Verschelden G,Hunter JD,Carson GD

    更新日期:1984-08-01 00:00:00

  • A study of the relationship between Goodwin's high-risk score and fetal outcome.

    abstract::Correlation between Goodwin's high-risk score and Apgar score was studied in 266 pregnancies managed with the use of the information from clinical monitoring. The correlation coefficients between Goodwin's score and Apgar scores were -0.3178 for one-minute Apgar scores and -0.2668 for five-minute Apgar scores. Both ar...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(77)90313-1

    authors: Yeh SY,Forsythe A,Lowensohn RI,Hon EH

    更新日期:1977-01-01 00:00:00

  • Early menopause and the risk of myocardial infarction.

    abstract::We evaluated the relation between age at menopause and the risk of nonfatal myocardial infarction (MI) among 121,964 nurses who responded to a mail questionnaire. Of 279 women who reported having been hospitalized for MI, 123 (44%) were postmenopausal (i.e., no longer menstruating) at the time of hospitalization, comp...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(81)90410-5

    authors: Rosenberg L,Hennekens CH,Rosner B,Belanger C,Rothman KJ,Speizer FE

    更新日期:1981-01-01 00:00:00

  • Infectious morbidity after primary cesarean sections in a private institution.

    abstract::Primary cesarean sections were performed on 395 patients between January 1, and December 31, 1976. A retrospective review of 322 of these patients indicated that the incidence of postoperative intrauterine infection was the same in both monitored and nonmonitored patients. The incidence of postoperative intrauterine i...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(80)90597-9

    authors: Anstey JT,Sheldon GW,Blythe JG

    更新日期:1980-01-15 00:00:00

  • Zinc transport in pregnancy.

    abstract::Although the importance of zinc nutrition during pregnancy has been well recognized, there have been few studies of zinc transport in maternal or fetal sera. We examined total serum zinc levels as well as zinc associated with its major transport proteins, albumin and alpha 2-macroglobulin, prospectively in 46 women du...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(84)90029-2

    authors: Zimmerman AW,Dunham BS,Nochimson DJ,Kaplan BM,Clive JM,Kunkel SL

    更新日期:1984-07-01 00:00:00

  • SOD1 overexpression in vivo blocks hyperglycemia-induced specific PKC isoforms: substrate activation and consequent lipid peroxidation in diabetic embryopathy.

    abstract:OBJECTIVE:Oxidative stress plays a causative role in diabetic embryopathy. We tested whether mitigating oxidative stress, using superoxide dismutase 1 (SOD1) transgenic (Tg) mice, would block hyperglycemia-induced specific protein kinase C (PKC) isoform activation and its downstream cascade. STUDY DESIGN:Day 8.5 embry...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2011.02.071

    authors: Li X,Weng H,Reece EA,Yang P

    更新日期:2011-07-01 00:00:00

  • Enhancement of amniotic cyclooxygenase type 2 activity in women with preterm delivery associated with twins or polyhydramnios.

    abstract:OBJECTIVE:We tested the hypothesis that preterm delivery in women with twins or polyhydramnios is associated with enhanced expression and activity of cyclooxygenase type 2 in the amnion. STUDY DESIGN:We obtained amniotic tissue samples from women undergoing preterm delivery complicated by either twins or polyhydramnio...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1067/mob.2001.108076

    authors: Leguizamón G,Smith J,Younis H,Nelson DM,Sadovsky Y

    更新日期:2001-01-01 00:00:00

  • Positive groin lymph nodes in superficial squamous cell vulvar cancer. A Gynecologic Oncology Group Study.

    abstract::The term microinvasive carcinoma is inappropriate when applied to all vulvar cancers less than or equal to 5 mm thick because approximately 50% of vulvar carcinomas are no thicker than 5 mm and 20% of those superficial tumors metastasize to the lymph nodes. The significant predictors of groin node metastases in patien...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(87)90132-3

    authors: Sedlis A,Homesley H,Bundy BN,Marshall R,Yordan E,Hacker N,Lee JH,Whitney C

    更新日期:1987-05-01 00:00:00

  • Treatment of ovarian stromal tumors.

    abstract::Fifty-one patients with granulosa-cell tumors and nine patients with Sertoli-Leydig-cell tumors have been treated at the M. D. Anderson Hospital. The most important prognostic finding was the stage of the tumor when first seen. Conservative surgery was utilized in young patients with lesions confined to one ovary. Mor...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(76)90577-9

    authors: Schwartz PE,Smith JP

    更新日期:1976-06-01 00:00:00

  • Prepubertal labial adhesions: evaluation of a referral population.

    abstract:OBJECTIVE:The purpose of this study was to assess patient demographics, clinical presentation, response to previous treatment, and current evaluation of prepubertal girls referred for gynecologic care of labial agglutination. STUDY DESIGN:A retrospective chart review of all prepubertal female patients with labial aggl...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1067/mob.2002.126201

    authors: Bacon JL

    更新日期:2002-08-01 00:00:00

  • Progression and remission of pelvic organ prolapse: a longitudinal study of menopausal women.

    abstract:OBJECTIVE:The purpose of this study was to describe the natural history of pelvic organ prolapse after menopause. STUDY DESIGN:Over 2 to 8 years, participants in the estrogen plus progestin trial of the Women's Health Initiative at the University of California Davis had annual pelvic examinations, with an assessment o...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2003.07.017

    authors: Handa VL,Garrett E,Hendrix S,Gold E,Robbins J

    更新日期:2004-01-01 00:00:00

  • Laparoscopic incidental appendectomy during laparoscopic surgery for ovarian endometrioma.

    abstract:OBJECTIVE:We sought to investigate the safety and efficacy of laparoscopic incidental appendectomy during laparoscopic surgery for endometrioma. STUDY DESIGN:We conducted a retrospective study of 356 patients undergoing laparoscopic surgery for endometrioma with appendectomy (appendectomy group, n = 172) or not (nonap...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2010.08.042

    authors: Lee JH,Choi JS,Jeon SW,Son CE,Bae JW,Hong JH,Lee KW,Lee YS

    更新日期:2011-01-01 00:00:00

  • Oral contraceptives, clotting factors, and thrombosis.

    abstract::Oral contraceptives (OCs) raise the plasma levels of some clotting factors, especially factor VII. Until recently, however, there has been no evidence for a relationship between high levels of clotting factor and the onset of clinically manifest vascular disease. It has not been established, on a preliminary basis, th...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0002-9378(16)32484-x

    authors: Meade TW

    更新日期:1982-03-15 00:00:00

  • Young age as a prognostic factor in cervical cancer: results of a population-based study.

    abstract:OBJECTIVE:Our goal was to use population-based data to determine the difference in 5-year survival in women diagnosed with cervical cancer between those aged 18-34 years and those aged 40-60 years. STUDY DESIGN:The SEER (Surveillance, Epidemiology, and End Results) public-use database, 1973-1994, was used for this inv...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0002-9378(99)70038-4

    authors: Brewster WR,DiSaia PJ,Monk BJ,Ziogas A,Yamada SD,Anton-Culver H

    更新日期:1999-06-01 00:00:00

  • Transplantation of fetal cells.

    abstract::Cellular transplantation is an attractive alternative to whole-organ transplantation when only a discrete function of the organ is deficient. Early fetal donor cells have an advantage because they engraft readily and do not cause graft-versus-host disease. Similarly, the fetus is an ideal recipient of allogeneic fetal...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1016/0002-9378(91)90656-c

    authors: Crombleholme TM,Langer JC,Harrison MR,Zanjani ED

    更新日期:1991-01-01 00:00:00

  • Preterm twins: what threshold of birth weight discordance heralds major adverse neonatal outcome?

    abstract:OBJECTIVE:This study was undertaken to establish the optimal threshold of birth weight discordance for prediction of adverse outcome in liveborn, non-malformed preterm twins. STUDY DESIGN:We accessed a cohort of twin gestations for the period 1990 through 2000 delivered at less than 37.0 weeks' gestation. Adverse neon...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2004.05.053

    authors: Vergani P,Locatelli A,Ratti M,Scian A,Pozzi E,Pezzullo JC,Ghidini A

    更新日期:2004-10-01 00:00:00

  • Conservative conization for microinvasive carcinoma of the cervix.

    abstract:OBJECTIVE:Our purpose was to examine conservative conization as treatment for microinvasive carcinoma of the cervix with depth of invasion < 3 mm. STUDY DESIGN:Twelve patients with microinvasive carcinoma of the cervix underwent cervical conization under colposcopic guidance followed by careful observation. RESULTS:T...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0002-9378(97)70394-6

    authors: Tseng CJ,Horng SG,Soong YK,Hsueh S,Hsieh CH,Lin HW

    更新日期:1997-05-01 00:00:00

  • Amniotic fluid prolactin levels and lecithin/sphingomyelin ratios during the third trimester of human gestation.

    abstract::Prolactin levels in amniotic fluid during the third trimester of human pregnancy showed a wide range of values. There was no apparent correlation between amniotic fluid prolactin concentrations (AF PRL) and lecithin/sphingomyelin (L/S) ratios nor was there a prolactin concentration associated with a mature L/S ratio. ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(81)90321-5

    authors: Hatjis CG,Wu CH,Gabbe SG

    更新日期:1981-02-15 00:00:00

  • Maternal catecholamines decrease during labor after lumbar epidural anesthesia.

    abstract::To determine whether epidural anesthesia during labor affects maternal circulating catecholamines, blood samples were obtained from 15 patients at the peak of and immediately after two consecutive painful contractions. A lumbar epidural local anesthetic without epinephrine was then administered. After the onset of ana...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(83)90076-5

    authors: Shnider SM,Abboud TK,Artal R,Henriksen EH,Stefani SJ,Levinson G

    更新日期:1983-09-01 00:00:00

  • Nonspontaneous late preterm birth: etiology and outcomes.

    abstract:OBJECTIVE:We sought to determine the proportion of evidence-based (EB), vs non-EB (NEB) iatrogenic late preterm birth, and to compare corresponding rates of neonatal intensive care unit (NICU) admission. STUDY DESIGN:We performed a retrospective cohort study. Cases were categorized as EB or NEB. NICU admission was com...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2011.08.007

    authors: Gyamfi-Bannerman C,Fuchs KM,Young OM,Hoffman MK

    更新日期:2011-11-01 00:00:00

  • Transplacental cardiovascular effects of four popular analgesics in rats.

    abstract::The purpose of this study is to clarify fetal cardiovascular effects of four popular analgesics administered to a maternal animal model. Clinical doses of aspirin (14 mg/kg), acetaminophen (14 mg/kg), ibuprofen (6 mg/kg), or indomethacin (0.7 mg/kg) were administered orally to near-term rats. At 1, 4, 8, or 24 hours l...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(90)90042-6

    authors: Momma K,Takao A

    更新日期:1990-05-01 00:00:00

  • Use of a new platelet function analyzer to detect von Willebrand disease in women with menorrhagia.

    abstract:OBJECTIVE:The purpose of this study was to assess the usefulness of a new platelet function analyzer in the detection of von Willebrand disease and platelet dysfunction in women with menorrhagia. STUDY DESIGN:Women with menorrhagia and control subjects were tested with a platelet function analyzer. If the results were...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2004.03.009

    authors: James AH,Lukes AS,Brancazio LR,Thames E,Ortel TL

    更新日期:2004-08-01 00:00:00

  • Does route of delivery affect maternal and perinatal outcome in women with eclampsia? A randomized controlled pilot study.

    abstract:OBJECTIVE:The route of delivery in eclampsia is controversial. We hypothesized that adverse maternal and perinatal outcomes may not be improved by early cesarean delivery. STUDY DESIGN:This was a randomized controlled exploratory trial carried out in a rural teaching institution. In all, 200 eclampsia cases, carrying ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.ajog.2012.04.009

    authors: Seal SL,Ghosh D,Kamilya G,Mukherji J,Hazra A,Garain P

    更新日期:2012-06-01 00:00:00

  • Endometrial ablation by means of photodynamic therapy with photofrin II.

    abstract:OBJECTIVE:Photodynamic therapy is a technique in which tissue is irradiated with light after the use of a photosensitizing drug that produces singlet oxygen, which has a cytotoxic effect. The feasibility of using photodynamic therapy with photofrin II for endometrial ablation was studied. STUDY DESIGN:Fifty-eight rabb...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(92)91787-b

    authors: Bhatta N,Anderson RR,Flotte T,Schiff I,Hasan T,Nishioka NS

    更新日期:1992-12-01 00:00:00

  • Cerclage for cervical shortening at fetoscopic laser photocoagulation in twin-twin transfusion syndrome.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the benefit of cervical cerclage for cervical length ≤ 25 mm at the time of fetoscopic laser photocoagulation (FLP) for twin-twin transfusion syndrome. STUDY DESIGN:A multicenter, retrospective cohort study was conducted with 163 patients with a short cervix before F...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ajog.2012.02.022

    authors: Papanna R,Habli M,Baschat AA,Bebbington M,Mann LK,Johnson A,Ryan G,Walker M,Lewis D,Harman C,Crombleholme T,Moise KJ Jr

    更新日期:2012-05-01 00:00:00

  • The effect of peritoneal fluid from patients with endometriosis on human sperm function in vitro.

    abstract:OBJECTIVE:Our purpose was to evaluate the effect of peritoneal fluid from women with endometriosis on sperm motility and function in an in vitro model. STUDY DESIGN:Peritoneal fluid was collected at laparoscopy from patients with and without endometriosis. Human donor sperm was diluted with this fluid, and its effect ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0002-9378(96)70210-7

    authors: Aeby TC,Huang T,Nakayama RT

    更新日期:1996-06-01 00:00:00

  • The relationship of blood lead levels to obstetric outcome.

    abstract::Lead represents a significant environmental hazard to pregnant women and their offspring. Exposure to high environmental levels of lead has been associated with spontaneous abortion, premature rupture of fetal membranes (PROM), and preterm delivery. The relationship between lower exposures and obstetric complications ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0002-9378(16)32282-7

    authors: Angell NF,Lavery JP

    更新日期:1982-01-01 00:00:00

  • Preterm premature rupture of membranes: vascular endothelial growth factor and its association with histologic chorioamnionitis.

    abstract:OBJECTIVE:We hypothesize that vascular endothelial growth factor, a known angiogenic and permeability factor that is locally expressed in fetal membranes and decidua, may be the primary regulator in the pathway that eventually leads to preterm premature rupture of membranes. Our objective was to test the hypothesis tha...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1067/mob.2002.127145

    authors: Daneshmand SS,Chmait RH,Moore TR,Bogic L

    更新日期:2002-11-01 00:00:00

  • The role of blood gas and acid-base assessment in the diagnosis of intrapartum fetal asphyxia.

    abstract::The diagnosis of fetal asphyxia requires a blood gas and acid-base assessment demonstrating a significant metabolic acidosis. However, the fetus may tolerate an asphyxial insult without central nervous system injury because of the fetal cardiovascular adaptation to hypoxemia. Prediction of the significance of an asphy...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,评审

    doi:10.1016/0002-9378(88)90456-5

    authors: Low JA

    更新日期:1988-11-01 00:00:00

  • Eclampsia. VI. Maternal-perinatal outcome in 254 consecutive cases.

    abstract::During a 12-year period, 254 cases of eclampsia were managed at this center. Eighty patients (32%) did not have edema, 58 (23%) had "relative hypertension," and 49 (19%) did not have proteinuria at the time of convulsions. Eclampsia developed at less than or equal to 20 weeks in 6 patients and beyond 48 hours post par...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(90)91123-t

    authors: Sibai BM

    更新日期:1990-09-01 00:00:00