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Does route of delivery affect maternal and perinatal outcome in women with eclampsia? A randomized controlled pilot study.

Abstract：

OBJECTIVE:The route of delivery in eclampsia is controversial. We hypothesized that adverse maternal and perinatal outcomes may not be improved by early cesarean delivery. STUDY DESIGN:This was a randomized controlled exploratory trial carried out in a rural teaching institution. In all, 200 eclampsia cases, carrying ≥34 weeks, were allocated to either cesarean or vaginal delivery. Composite maternal and perinatal event rates (death and severe morbidity) were compared by intention-to-treat principle. RESULTS:Groups were comparable at baseline with respect to age and key clinical parameters. Maternal event rate was similar: 10.89% in the cesarean arm vs 7.07% for vaginal delivery (relative risk, 1.54; 95% confidence interval, 0.62-3.81). Although the neonatal event rate was less in cesarean delivery-9.90% vs 19.19% (relative risk, 0.52; 95% confidence interval, 0.25-1.05)-the difference was not significant statistically. CONCLUSION:A policy of early cesarean delivery in eclampsia, carrying ≥34 weeks, is not associated with better outcomes.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Seal SL,Ghosh D,Kamilya G,Mukherji J,Hazra A,Garain P

doi

10.1016/j.ajog.2012.04.009

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

484.e1-7

issue

6

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(12)00387-0

journal_volume

206

pub_type

杂志文章,随机对照试验

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