Sex hormone--binding globulin--a surrogate marker for the prothrombotic effects of combined oral contraceptives.

Abstract:

OBJECTIVE:The purpose of this study was to investigate the plausibility of serum sex hormone-binding globulin (SHBG) concentration as a risk marker for venous thromboembolism (VTE) during use of combined oral contraceptives (COC). Study design This was a prospective, randomized cross-over study. Thirty-five women were treated with COCs containing the same amount of ethinyl estradiol and either levonorgestrel (LNG/EE) or desogestrel (DG/EE). Serum SHBG and markers of hemostasis were determined before and after 2 months on each treatment. RESULTS:SHBG increased significantly with both preparations. Treatment with DG/EE caused more pronounced prothrombotic changes in hemostatic parameters than LNG/EE. With both treatment regimens, there was a significant correlation between changes in resistance to activated protein C (APCr) and changes in plasma SHBG. CONCLUSION:The correlation between SHBG and the well-established risk factor APCr might indicate the usefulness of SHBG as a risk marker for VTE during COC treatment.

journal_name

Am J Obstet Gynecol

authors

van Rooijen M,Silveira A,Hamsten A,Bremme K

doi

10.1016/s0002-9378(03)00950-5

subject

Has Abstract

pub_date

2004-02-01 00:00:00

pages

332-7

issue

2

eissn

0002-9378

issn

1097-6868

pii

S0002937803009505

journal_volume

190

pub_type

临床试验,杂志文章,随机对照试验
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    abstract:BACKGROUND:The integrity of the pelvic autonomic nervous system is essential for proper bowel, bladder, and sexual function. OBJECTIVE:The purpose of this study was to characterize the anatomic path of the pelvic autonomic system and to examine relationships to clinically useful landmarks. STUDY DESIGN:Detailed disse...

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    pub_type: 杂志文章

    doi:10.1016/j.ajog.2016.12.002

    authors: Ripperda CM,Jackson LA,Phelan JN,Carrick KS,Corton MM

    更新日期:2017-04-01 00:00:00

  • Quality of intrapartum cardiotocography in twin deliveries.

    abstract:OBJECTIVE:Intrapartum fetal heart rate (FHR) recordings in twins were compared for fetal signal loss during both stages of labor to assess the quality of these recordings by the method that had been used: external ultrasound or directly via a scalp electrode. STUDY DESIGN:Analysis of recordings collected between Janua...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2004.04.037

    authors: Bakker PC,Colenbrander GJ,Verstraeten AA,Van Geijn HP

    更新日期:2004-12-01 00:00:00

  • Conservative treatment of ectopic pregnancy with methotrexate.

    abstract::Six subjects with distal ampullary ectopic pregnancies were treated with four doses of intravenous methotrexate (1.0 mg/kg) followed by four doses of leucovorin (0.1 mg/kg, intramuscularly). The diagnosis was established in all cases by laparoscopy following sonography and radioimmunoassay for serum beta subunit of hu...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(86)90716-7

    authors: Ory SJ,Villanueva AL,Sand PK,Tamura RK

    更新日期:1986-06-01 00:00:00

  • Activation of NF-kappaB and expression of COX-2 in association with neutrophil infiltration in systemic vascular tissue of women with preeclampsia.

    abstract:OBJECTIVE:The purpose of this study was to determine whether activation of NF-kappaB and expression of COX-2 are associated with neutrophil infiltration in systemic vascular tissue of women with preeclampsia. STUDY DESIGN:Subcutaneous fat biopsies were obtained at cesarean section or abdominal surgery from preeclampti...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2006.08.038

    authors: Shah TJ,Walsh SW

    更新日期:2007-01-01 00:00:00

  • Relationships between prenatal medical and nutritional measures, pregnancy outcome, and early infant development in an urban poverty setting. I. The role of nutritional intake.

    abstract::Repeated nutritional assessments were made on 118 low-income women who registered at an urban hospital clinic prior to the twenty-eighth week of pregnancy and then on 122 comparable women who were provided with protein-mineral supplementation. Demographic and background information were obtained. Medical assessments w...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(75)90487-1

    authors: Osofsky HJ

    更新日期:1975-12-01 00:00:00

  • Incisions of the pregnant uterus and delivery of low-birth weight infants.

    abstract::This paper calls attention to rapidly increased use of vertical uterine incision and future consequences: impaired uterus, uterine rupture, and iatrogenic premature delivery. In addition, by making a vertical uterine incision we are not gaining much in the size of uterine entrance since the size of the vertical uterin...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(85)90541-1

    authors: Jovanovic R

    更新日期:1985-08-15 00:00:00

  • The uterine contractility index: a research and diagnostic tool in dysmenorrhea.

    abstract::Women who experienced severe primary dysmenorrhea had 90 to 120 minutes of continuous uterine pressure monitoring during their peak period of discomfort. During the initial screening cycle, they were given 40 mg of piroxicam, a nonsteroidal anti-inflammatory drug which inhibits prostaglandin synthesis. The pressure tr...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章

    doi:10.1016/0002-9378(83)90865-7

    authors: Schulman H,Duvivier R,Blattner P

    更新日期:1983-04-15 00:00:00

  • Randomized trial of prophylactic antibiotic therapy after preterm amnion rupture.

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    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0002-9378(93)90038-k

    authors: Owen J,Groome LJ,Hauth JC

    更新日期:1993-10-01 00:00:00

  • Congenital heart block: successful prophylactic treatment with intravenous gamma globulin and corticosteroid therapy.

    abstract::In mothers with anti-Ro-positive antibodies whose previous pregnancies have ended in deliveries of infants with congenital heart block, prophylactic therapeutic strategies are used to try to diminish the production and passage into fetal circulation of autoantibodies. Intravenous gamma globulin was given at 14 and 18 ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(91)90362-u

    authors: Kaaja R,Julkunen H,Ammälä P,Teppo AM,Kurki P

    更新日期:1991-11-01 00:00:00

  • No evidence for lipid peroxidation in severe preeclampsia.

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    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1067/mob.2001.116754

    authors: Regan CL,Levine RJ,Baird DD,Ewell MG,Martz KL,Sibai BM,Rokach J,Lawson JA,Fitzgerald GA

    更新日期:2001-09-01 00:00:00

  • Risks and consequences of puerperal uterine inversion in the United States, 2004 through 2013.

    abstract:BACKGROUND:Puerperal uterine inversion is a rare, potentially life-threatening obstetrical emergency. The current literature consists of small case series and a single nationwide study from Europe with only 15 cases. OBJECTIVE:We aimed to define the incidence, temporal trends, and outcomes in women with uterine invers...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2017.05.018

    authors: Coad SL,Dahlgren LS,Hutcheon JA

    更新日期:2017-09-01 00:00:00

  • Laminaria versus extra-amniotic saline solution infusion for cervical ripening in second-trimester labor inductions.

    abstract:OBJECTIVE:The aim of this study was to determine which cervical ripening method, laminaria placement or extra-amniotic saline solution infusion, was associated with the shorter interval from induction to delivery in the second trimester. STUDY DESIGN:Women admitted for indicated second-trimester labor induction with a...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1067/mob.2001.112903

    authors: Hogg BB,Owen J

    更新日期:2001-05-01 00:00:00

  • Very-low-birth-weight outcomes of the National Institute of Child Health and Human Development Neonatal Research Network, May 1991 through December 1992.

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    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/0002-9378(95)90628-2

    authors: Fanaroff AA,Wright LL,Stevenson DK,Shankaran S,Donovan EF,Ehrenkranz RA,Younes N,Korones SB,Stoll BJ,Tyson JE

    更新日期:1995-11-01 00:00:00

  • Intrauterine and extrauterine growth of cranial perimeter in term and preterm infants. A longitudinal study.

    abstract::In this study a cranial perimeter curve was established from 13 weeks of gestation to 6 months of postnatal life. Thirty cases were studied. The intrauterine section of the curve was derived from data obtained weekly by echography. The tenth and fiftieth percentiles of fetal measurements were greater than those descri...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(83)90248-x

    authors: Fescina RH,Martell M

    更新日期:1983-12-15 00:00:00

  • Urethral circular smooth muscle in young and old women.

    abstract:OBJECTIVE:The purpose of this study was to determine whether thickness, fiber count, and density of urethral circular smooth muscle (CSM) differ in young and old women. STUDY DESIGN:Mid urethral hemiaxial sections from female cadavers aged 20-39 years (n = 12) and 70-89 years (n = 16) were stained for smooth muscle al...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2008.03.009

    authors: Clobes A,DeLancey JO,Morgan DM

    更新日期:2008-05-01 00:00:00

  • Effects of terbutaline sulfate on fetal cardiac function.

    abstract::An isolated heart preparation was used to study the effects of terbutaline sulfate (Brethine) on fetal cardiac function. Pregnant guinea pigs received daily subcutaneous injections of terbutaline for 10 day, whereas a control group received placebo injections. Fetal guinea pig hearts were evaluated for cariodynamic an...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(89)90346-3

    authors: Petersen R,Carter LS,Chescheir NC,Katz VL,Cefalo RC

    更新日期:1989-09-01 00:00:00

  • Studies on the decreased gonadotropin response after administartion of LH-FSH-releasing hormone during pregnancy and the puerperium.

    abstract::The responsiveness of the pituitary to luteinizing hormone releasing hormone (LRH) during pregnancy and the puerperium was studied in 15 women 18-32 years of age (3 puerperal, 6 pregnant, and 6 eumenorrheic). 25 mcg LRH dissolved in 1 ml sterile water was administered iv to all the subjects. Blood samples were obtai...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(74)90145-8

    authors: Jeppsson S,Rannevik G,Kullander S

    更新日期:1974-12-15 00:00:00

  • Recurrence of preeclampsia: effects of gestational age at delivery of the first pregnancy, body mass index, paternity, and interval between births.

    abstract:OBJECTIVES:The purpose of this study was to establish estimates for recurrence risk of preeclampsia based on gestational age at delivery of the first pregnancy complicated by preeclampsia and to determine whether interbirth interval, paternity, and body mass index (BMI) modify that risk in women with prior preeclampsia...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2007.11.058

    authors: Mostello D,Kallogjeri D,Tungsiripat R,Leet T

    更新日期:2008-07-01 00:00:00

  • Photosensitization of the endometrium with topical 5-aminolevulinic acid.

    abstract::Photosensitization of the endometrium was attempted in vitro and in vivo by intrauterine administration of 5-aminolevulinic acid, which is converted to the photosensitizer protoporphyrin IX. Protoporphyrin IX was found in both functional and basal layers of the endometrial glands at concentrations nine and 10 times hi...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(95)90435-2

    authors: Gannon MJ,Johnson N,Roberts DJ,Holroyd JA,Vernon DI,Brown SB,Lilford RJ

    更新日期:1995-12-01 00:00:00

  • Prenatal diagnosis of symptomatic congenital cytomegalovirus infection.

    abstract:OBJECTIVE:The aim of this study was to evaluate whether the amniotic viral load of mothers with primary cytomegalovirus infection correlate with fetal or neonatal outcomes. STUDY DESIGN:Sixty-eight of 138 pregnant women with primary infection defined by immunoglobulin G seroconversion or the presence of immunoglobulin...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1067/mob.2000.106347

    authors: Guerra B,Lazzarotto T,Quarta S,Lanari M,Bovicelli L,Nicolosi A,Landini MP

    更新日期:2000-08-01 00:00:00

  • Gestational age limit of twelve weeks for abortion by curettage.

    abstract::A brief review of the evidence for and against the 12-week gestational age limit for abortion by curettage is reported. Existing data suggest that second trimester evacuation abortion is associated with higher morbidity and mortality rates than first trimester suction curettage, but with lower rates than second trime...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(78)90925-0

    authors: Grimes DA,Cates W Jr

    更新日期:1978-09-15 00:00:00

  • The prevention of postoperative pelvic adhesions: an animal study comparing barrier methods with dextran 70.

    abstract::There are two major approaches to the prophylaxis for adhesions: chemical methods (e.g., dextran) and barrier methods. Theoretically, dextran prevents the formation of adhesions by a surface-coating or hydroflotation effect, whereas the barrier methods either prevent the formation of or mask adhesions by covering and ...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(82)90018-7

    authors: Soules MR,Dennis L,Bosarge A,Moore DE

    更新日期:1982-08-01 00:00:00

  • Maternal obesity and risk of stillbirth: a metaanalysis.

    abstract::We conducted this metaanalysis to summarize the available epidemiologic evidence on the relationship between maternal overweight and obesity and the risk of stillbirth. We identified studies from 3 sources: (1) a PubMed search of relevant articles that were published between January 1980 and September 2005, (2) refere...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章,meta分析,评审

    doi:10.1016/j.ajog.2007.03.027

    authors: Chu SY,Kim SY,Lau J,Schmid CH,Dietz PM,Callaghan WM,Curtis KM

    更新日期:2007-09-01 00:00:00

  • Outcome of corticotropin stimulation testing in women with androgen excess and ovulatory dysfunction.

    abstract:OBJECTIVE:Our objective was to evaluate women with clinical signs or chemical evidence of androgen excess by corticotropin stimulation testing. STUDY DESIGN:Seventy-six women with evidence of androgen excess were evaluated by corticotropin stimulation testing. Results were examined by plasma levels of dehydroepiandros...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0002-9378(11)91406-9

    authors: Bates GW,French GM,Humphries BB,Blackhurst DW

    更新日期:1992-08-01 00:00:00

  • Combined ultrasonographically guided drainage and laparoscopic excision of a large ovarian cyst.

    abstract::Large ovarian cysts are conventionally treated by laparotomy. We describe a technique of transabdominal drainage under ultrasonographic control followed by laparoscopic excision of an ovarian cyst that was 24 x 10 x 20 cm. This approach has the benefits of minimal-access surgery and is suitable for unilocular benign c...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/s0002-9378(96)70060-1

    authors: Nagele F,Magos AL

    更新日期:1996-11-01 00:00:00

  • Deoxyribonucleic acid ploidy and S-phase fraction are not significant prognostic factors for patients with cervical cancer.

    abstract:OBJECTIVE:Our purpose was to determine the usefulness of deoxyribonucleic acid ploidy and S-phase fraction as prognostic factors in patients with cervical cancer. STUDY DESIGN:Paraffin-embedded tumor specimens were obtained from 123 patients with cervical cancer (mean age 51 years, range 21 to 87 years). The mean foll...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(94)90394-8

    authors: Jelen I,Valente PT,Gautreaux L,Clark GM

    更新日期:1994-12-01 00:00:00

  • Are choroid plexus cysts an indication for second-trimester amniocentesis?

    abstract::Previous series that described fetuses with choroid plexus cysts have been too small to determine whether there is an association with trisomy 18 sufficiently high to warrant amniocentesis. To address this issue, we studied the incidence of choroid plexus cysts and other ultrasonographic abnormalities in 26 consecutiv...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/0002-9378(90)91304-u

    authors: Benacerraf BR,Harlow B,Frigoletto FD Jr

    更新日期:1990-04-01 00:00:00

  • Is transobturator tape as effective as tension-free vaginal tape in patients with borderline maximum urethral closure pressure?

    abstract:INTRODUCTION:The purpose of this study was to compare transobturator tape (MONARC) with tension-free vaginal tape in patients with borderline low maximum urethral closure pressure. STUDY DESIGN:Historical cohort analysis of 3-month outcomes in 145 subjects (MONARC = 85; tension-free vaginal tape = 60). A cut-off point...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2006.07.011

    authors: Miller JJ,Botros SM,Akl MN,Aschkenazi SO,Beaumont JL,Goldberg RP,Sand PK

    更新日期:2006-12-01 00:00:00

  • Symptoms of anal incontinence and difficult defecation among women with prolapse and a matched control cohort.

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    journal_title:American journal of obstetrics and gynecology

    pub_type: 杂志文章

    doi:10.1016/j.ajog.2007.03.074

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    更新日期:2007-11-01 00:00:00

  • Prophylactic administration of progesterone by vaginal suppository to reduce the incidence of spontaneous preterm birth in women at increased risk: a randomized placebo-controlled double-blind study.

    abstract:OBJECTIVE:The purpose of this study was to evaluate the effect of prophylactic vaginal progesterone in decreasing preterm birth rate in a high-risk population. STUDY DESIGN:A randomized, double-blind, placebo-controlled study included 142 high-risk singleton pregnancies. Progesterone (100 mg) or placebo was administer...

    journal_title:American journal of obstetrics and gynecology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1067/mob.2003.41

    authors: da Fonseca EB,Bittar RE,Carvalho MH,Zugaib M

    更新日期:2003-02-01 00:00:00