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Repeat doses of antenatal steroids and hypothalamic-pituitary-adrenal axis (HPA) function.

Abstract：

OBJECTIVE:This study was undertaken to compare the effects of exposure to repeated courses of antenatal steroids with those of a single course on hypothalamic-pituitary-adrenal axis function. STUDY DESIGN:Women at risk of premature delivery were assessed for entry into a randomized controlled trial of repeated courses of corticosteroids (ACTORDS). If a woman declined the randomized trial then consent was sought for collection of observational data. Baseline bloods for cortisol and adrenocorticotropic hormone levels were collected and in a subset of infants a metyrapone test performed. RESULTS:In the 86 studied infants, cortisol and adrenocorticotropic hormone levels did not differ between those exposed to single and repeated courses of antenatal steroids (P = .53 and P = .15, respectively). Although cortisol levels fell in response to metyrapone (P = .03) this response was not different between the single and repeated course groups (P = .46). CONCLUSION:Repeated courses of antenatal steroids do not cause important hypothalamic-pituitary-adrenal axis suppression in the neonate.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Battin MR,Bevan C,Harding JE

doi

10.1016/j.ajog.2007.02.015

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

40.e1-6

issue

1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(07)00249-9

journal_volume

197

pub_type

杂志文章,随机对照试验

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