Cocaine's effect on plasma oxytocin concentrations in the baboon during late pregnancy.

Abstract:

OBJECTIVE:The hypothesis for this investigation was that intravenous cocaine would result in an elevation of maternal plasma oxytocin levels in the baboon during late pregnancy. STUDY DESIGN:Five gravid chronically instrumented baboons had timed arterial blood samples obtained before and after an intravenous bolus cocaine infusion at least 5 days after surgery. Plasma oxytocin concentrations were measured by specific radioimmunoassays, and baseline samples were compared with postcocaine samples. RESULTS:The plasma oxytocin concentrations were significantly elevated at all sampling times after the 1.0 mg/kg cocaine dose (p<0.05). CONCLUSION:The increased oxytocin concentration after cocaine use may be responsible for the increased incidence of preterm labor.

journal_name

Am J Obstet Gynecol

authors

Morgan MA,Honnebier MB,Mecenas C,Nathanielsz PW

doi

10.1016/s0002-9378(96)70344-7

subject

Has Abstract

pub_date

1996-03-01 00:00:00

pages

1026-7

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(96)70344-7

journal_volume

174

pub_type

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