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Nifedipine: effects on fetal and maternal hemodynamics in pregnant sheep.

Abstract：

:We investigated the effects of nifedipine, a calcium entry blocker, on the fetal and maternal circulation. Nifedipine was administered intravenously for 30 minutes to chronically instrumented pregnant ewes. Infusion of 5 micrograms.kg-1.min-1 resulted in a 30% to 50% increase in total and regional fetal cerebral blood flow to the brain stem, watershed, and subcortical regions (p less than 0.05), without a significant change in fetal oxygenation or cardiac output. Infusion of 10 micrograms.kg-1.min-1 decreased uterine blood flow by 21% (p less than 0.001) and fetal arterial oxygen content by 15% (p less than 0.01), with no further increase in fetal cerebral blood flow. Maternal arterial pressure decreased and heart rate increased (p less than 0.001) without variation of arterial blood gases. Significant plasma levels of nifedipine were detected in the fetal and maternal circulations. In view of the potential adverse effects on the fetus, further studies are needed before nifedipine is considered for use in human pregnancy.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Harake B,Gilbert RD,Ashwal S,Power GG

doi

10.1016/s0002-9378(87)80104-7

subject

Has Abstract

pub_date

1987-10-01 00:00:00

pages

1003-8

issue

4 Pt 1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(87)80104-7

journal_volume

157

pub_type

杂志文章

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