Abstract：
OBJECTIVE:Our purpose was to determine whether the biguanide oral antihyperglycemic agent metformin increases human placental uptake and transport of glucose to the fetal circulation. STUDY DESIGN:The human single-cotyledon model was used to compare transport of tritiated glucose in the maternal to fetal direction in eight human placentas between control placentas and those exposed to metformin in vitro. Transport was calculated from the serial perfusate glucose levels obtained in each 3-hour experiment, and placental uptake was determined from homogenates of the perfused cotyledon. Liquid scintillation spectrometry measured levels of both glucose and the reference substance antipyrine. Transport was compared by the Mann-Whitney U test. RESULTS:Mean maternal and fetal glucose levels were 77.5 +/- 4.9 mg/dl and 61.3 +/- 5.9 mg/dl, respectively, in the metformin group and 83.8 +/- 4.3 mg/dl and 60.4 +/- 12.4 mg/dl, respectively, in controls at 2 hours. Placental glucose uptake was 91.1 +/- 42.2 microg/gm placenta in the metformin experiments and 104.9 +/- 76.9 microg/gm placenta in controls. No difference in placental glucose uptake or transport could be demonstrated. CONCLUSION:Metformin does not affect human placental glucose uptake or transport.
journal_name
Am J Obstet Gynecoljournal_title
American journal of obstetrics and gynecologyauthors
Elliott BD,Langer O,Schuessling Fdoi
10.1016/s0002-9378(97)70541-6subject
Has Abstractpub_date
1997-03-01 00:00:00pages
527-30issue
3eissn
0002-9378issn
1097-6868pii
S0002-9378(97)70541-6journal_volume
176pub_type
杂志文章abstract：BACKGROUND:Recommendations on preventing primary cesarean delivery removed the previously defined time limits for latent labor (defined as ending at 6 cm) and urged clinicians to avoid cesarean delivery for labor abnormalities in the latent phase. However, relatively little is known about the implications of labor curv...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2019.05.041
更新日期：2019-11-01 00:00:00
abstract：OBJECTIVE:We examined the use, safety, and economic impact of same-day discharge for women undergoing laparoscopic hysterectomy. STUDY DESIGN:We identified women in the Perspective database who underwent laparoscopic hysterectomy from 2000 through 2010. Discharge was classified as same-day, 1 day, and ≥2 days. Multiva...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2012.09.014
更新日期：2012-11-01 00:00:00
abstract：:We present a case of a primiparous patient at 35 weeks' gestation who had had laparoscopic gastric banding, and who presented to labor and delivery with protracted vomiting followed by an acute abdomen and fetal distress. An emergency surgery revealed acute gastric ulcer perforation. This complication, although rare, ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2004.03.036
更新日期：2004-11-01 00:00:00
abstract：OBJECTIVES:Our objectives were to determine in pregnancies complicated by diabetic nephropathy (1) if impedance to flow in the uterine and umbilical arteries is normal and (2) if these fetuses are hypoxemic and acidemic and if they have decreased fetal heart rate variation and Doppler blood flow redistribution. STUDY ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(11)91704-9
更新日期：1992-11-01 00:00:00
abstract：:An investigation was undertaken in an effort to learn whether the type of delivery or the pattern of labor progression has any lasting effect on the infant. Paired-data design was chosen to ensure that the comparisons between homogeneous groups would be valid. Our objective was to reduce potential bias based on unequa...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(84)90386-7
更新日期：1984-12-15 00:00:00
abstract：OBJECTIVE:We performed a systematic review and meta-analysis to determine whether D-mannose reduces urinary tract infection recurrence (ie, cumulative incidence) in adult women with recurrent urinary tract infection compared with other prevention agents. Secondary outcomes included side effects and compliance with D-ma...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,meta分析
doi：10.1016/j.ajog.2020.05.048
更新日期：2020-08-01 00:00:00
abstract：OBJECTIVE:Our purpose was to document noninvasively the effect of sickle cell disease on left ventricular systolic and diastolic function during the third trimester of pregnancy. STUDY DESIGN:Fifteen patients with sickle cell disease underwent a two-dimensional M-mode echocardiography obtained using the long axis with...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(94)70393-0
更新日期：1994-01-01 00:00:00
abstract：:A randomized prospective trial study was developed to determine the diagnostic value of the fetal biophysical profile in relationship to the nonstress test. The diagnostic values of these tests were assessed in terms of the incidence of abnormal outcome. In addition comparisons between the positive and negative predic...
journal_title：American journal of obstetrics and gynecology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1985-11-15 00:00:00
abstract：:Intrauterine 17 beta-estradiol pellets can induce an up-regulation of guinea pig myometrial beta-adrenergic receptor density and l-isoproterenol-dependent adenylate cyclase activity. Does 17 beta-estradiol influence the ability of beta-adrenergic receptors to form a "high affinity" state with l-isoproterenol, which is...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(89)90939-3
更新日期：1989-12-01 00:00:00
abstract：OBJECTIVE:Intrapartum fetal heart rate (FHR) recordings in twins were compared for fetal signal loss during both stages of labor to assess the quality of these recordings by the method that had been used: external ultrasound or directly via a scalp electrode. STUDY DESIGN:Analysis of recordings collected between Janua...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2004.04.037
更新日期：2004-12-01 00:00:00
abstract：:The neuropathologic conditions in 120 perinatal deaths attributed to fetal or newborn asphyxia were examined. Central nervous system necrosis was present in 16 of these deaths. The approximate time of asphyxial insult was established by determining the duration of the process, based on the findings of neuronal necrosi...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(89)80040-7
更新日期：1989-03-01 00:00:00
abstract：OBJECTIVE:The objective of this study was to determine the minimum threshold level at which maximum anatomic prolapse predicts bothersome pelvic floor symptoms. STUDY DESIGN:We performed a cross-sectional study of women older than 40 years undergoing gynecologic and urogynecologic examinations using Pelvic Organ Prola...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2008.07.028
更新日期：2008-12-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to determine the prevalence of burnout in chairs of academic departments of obstetrics and gynecology, identify important stressors, and develop strategies to treat and prevent burnout. STUDY DESIGN:We performed a cross-sectional study of 131 chairs in the United States and Puer...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1067/mob.2002.122391
更新日期：2002-04-01 00:00:00
abstract：:The technique and application of fine-needle aspiration cytology in the management of gynecologic cancer are discussed. The authors report 90 cases that have been evaluated by means of fine-needle technique. The technique has been applied both for primary diagnosis and for follow-up evaluation. Among the 90 cases repo...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(81)90437-3
更新日期：1981-01-15 00:00:00
abstract：OBJECTIVE:Our purpose was to immunolocalize urokinase-type plasminogen activator and the plasminogen activator inhibitors 1 and 2 in human implantation sites, with emphasis on the types of trophoblast expressing the plasminogen activator and the inhibitors. STUDY DESIGN:Urokinase and the plasminogen activator inhibito...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(94)70246-2
更新日期：1994-02-01 00:00:00
abstract：OBJECTIVE:We sought to determine the validity of colposcopically directed cervical biopsies as a diagnostic test to define the degree of cervical intraepithelial neoplasia (CIN). STUDY DESIGN:In a prospective multicenter trial, patients undergoing excisional procedures of the transformation zone additionally had colpo...
journal_title：American journal of obstetrics and gynecology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1016/j.ajog.2010.05.033
更新日期：2010-10-01 00:00:00
abstract：OBJECTIVE:The objective of the study was to examine the effect of first-trimester obstetric ultrasound (OBUS) on the measurement of the effect of complications ascribed to postterm pregnancies. STUDY DESIGN:We conducted a retrospective cohort study of all term, singleton pregnancies delivered at our institution who ha...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2008.03.034
更新日期：2008-06-01 00:00:00
abstract：OBJECTIVE:Our purpose was to compare the estimated maternal cerebral perfusion pressure and an index of vascular resistance, the resistance area product, in nonpregnant women with hypertensive pregnant women. STUDY DESIGN:The maternal middle cerebral artery was evaluated by transcranial Doppler ultrasonography in 17 n...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(98)70131-0
更新日期：1998-11-01 00:00:00
abstract：BACKGROUND:The ideal measure of success after surgery for pelvic organ prolapse has long been debated. Historically, strict definitions based on anatomic perfection have dominated the literature. However, the importance of patient-centered perception of outcomes is equally or more important when comparing the success o...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2020.10.009
更新日期：2020-10-08 00:00:00
abstract：OBJECTIVE:We sought to assess the prevalence of and risk factors for vaginal trichomoniasis in human immunodeficiency virus-infected and human immunodeficiency virus-uninfected pregnant Congolese women and its relationship to pregnancy outcomes. STUDY DESIGN:We performed a nested case-control study of 215 infected and...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(99)70509-0
更新日期：1999-09-01 00:00:00
abstract：:We report a case of extreme maldevelopment of embryonic body folding that resulted in incomplete fusion of the amnion to the chorion and failure to form an umbilical cord. Massive intra-abdominal and intrathoracic herniation led to rapid neonatal death. The accurate ultrasonic characterization of the defect enabled pr...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(86)90345-5
更新日期：1986-11-01 00:00:00
abstract：OBJECTIVE:This study was undertaken to determine whether preoperative radioimmunoscintigraphy of complex ovarian masses with technetium Tc 99m MAb-170 (Tru-Scint AD; Biomira Inc, Edmonton, Alberta, Canada), a murine whole immunoglobulin G monoclonal antibody that has been found to have panadenocarcinoma affinity, would...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1067/mob.2000.105938
更新日期：2000-09-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to evaluate sonohysterography in patients with endometrial cancer and to determine whether (1) transtubal fluid spill occurs during routine sonohysterography, (2) a critical infusion volume for spill exists, or (3) disseminated cancer cells demonstrate viability. STUDY DESIGN:At...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2008.03.042
更新日期：2008-09-01 00:00:00
abstract：OBJECTIVE:Our purpose was to examine conservative conization as treatment for microinvasive carcinoma of the cervix with depth of invasion < 3 mm. STUDY DESIGN:Twelve patients with microinvasive carcinoma of the cervix underwent cervical conization under colposcopic guidance followed by careful observation. RESULTS:T...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(97)70394-6
更新日期：1997-05-01 00:00:00
abstract：:One hundred forty-nine consecutive patients who had surgery from May 1890 through December 1986 were evaluated to assess the functional and anatomic results of the paravaginal defect repair for stress urinary incontinence. All patients had their preoperative assessment, operative procedure, and postoperative follow-up...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(89)90867-3
更新日期：1989-06-01 00:00:00
abstract：OBJECTIVE:Our objective was to study the effect of estrogen administration and moderate hypertension on left ventricular size, pump function, and contractility in chronically instrumented ewes. STUDY DESIGN:Ewes were either given 0.06 mg/kg 17beta-estradiol intramuscularly (n = 8) or were made hypertensive (n = 6) by ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(98)70053-5
更新日期：1998-09-01 00:00:00
abstract：:In order to determine whether intravenous injections of glucose could reverse the effects of maternal ingestion of ethanol (0.25 gm/kg), glucose (25 gm intravenously) or an equal volume of saline solution was administered to eight pregnant women at 37 to 40 weeks' gestation after ingestion of ethanol. Fetal breathing ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(84)90765-8
更新日期：1984-03-01 00:00:00
abstract：BACKGROUND:Use of more effective contraception may lead to less condom use and increased incidence of sexually transmitted infection. OBJECTIVE:The objective of this study was to compare changes in condom use and incidence of sexually transmitted infection acquisition among new initiators of long-acting reversible con...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2017.09.009
更新日期：2017-12-01 00:00:00
abstract：:Four hundred twenty-nine patients were entered into four prospective randomized clinical studies between January 1, 1973, and July 1, 1979. The records of 395 of these were analyzed to determine the proportion of patients surviving 48 months after therapy initiation. Ninety-six patients (24%) were living at 48 months,...
journal_title：American journal of obstetrics and gynecology
pub_type： 临床试验,杂志文章
doi：10.1016/0002-9378(84)90543-x
更新日期：1984-04-01 00:00:00
abstract：OBJECTIVE:An abnormal umbilical artery Doppler waveform is a risk factor for adverse perinatal outcome. However, it has not been established whether this is related to the earlier gestational age at delivery of fetuses with abnormal Doppler findings or whether Doppler findings are an independent predictor of perinatal ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(94)90087-6
更新日期：1994-09-01 00:00:00
