Abstract：
OBJECTIVE:Our purpose was to immunolocalize urokinase-type plasminogen activator and the plasminogen activator inhibitors 1 and 2 in human implantation sites, with emphasis on the types of trophoblast expressing the plasminogen activator and the inhibitors. STUDY DESIGN:Urokinase and the plasminogen activator inhibitors 1 and 2 were localized immunohistochemically in early human implantation sites in unruptured ectopic pregnancies from patients in an in vitro fertilization program. RESULTS:Urokinase kinase and the plasminogen activator inhibitors 1 and 2 were localized in the cytoplasm of cytotrophoblasts and in the cytoplasm and plasma membranes of intermediate and syncytiotrophoblast. Greater staining was noted in nonvillous, relative to villous, cytotrophoblasts for urokinase and both inhibitors. CONCLUSIONS:Urokinase-type plasminogen activator and the plasminogen activator inhibitors 1 and 2 were localized in all three forms of trophoblast at the maternal-fetal interface in early human implantation sites, particularly the differentiated and invasive forms of trophoblast. These results support a role for the plasminogen activator or inhibitors in the controlled invasion of the maternal decidua by the trophoblast during human implantation.
journal_name
Am J Obstet Gynecoljournal_title
American journal of obstetrics and gynecologyauthors
Hofmann GE,Glatstein I,Schatz F,Heller D,Deligdisch Ldoi
10.1016/s0002-9378(94)70246-2subject
Has Abstractpub_date
1994-02-01 00:00:00pages
671-6issue
2eissn
0002-9378issn
1097-6868pii
S0002937894004850journal_volume
170pub_type
杂志文章abstract：:Objections are made to the conclusions of Tolis and Naftolin that bromocriptine should be considered for induction of menstruation in women with normal serum prolactin. Amenorrhea with normal follicle stimulating hormone (FSH) and luteinizing hormone (LH) levels is often resolved spontaneously. Treatment with bromoc...
journal_title：American journal of obstetrics and gynecology
pub_type： 信件
doi：10.1016/0002-9378(78)90452-0
更新日期：1978-01-01 00:00:00
abstract：:The rates of regression of human chorionic gonadotropin (hCG) in patients with complete hydatidiform moles, partial hydatidiform moles, and nonmolar abortions were compared. No difference in rates of regression was found among the three groups, but levels of hCG immediately after uterine evacuation were significantly ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(84)90184-4
更新日期：1984-05-15 00:00:00
abstract：BACKGROUND:Polycystic ovary syndrome is the most common endocrine disorder affecting women of reproductive age. A number of criteria have been developed for clinical diagnosis of polycystic ovary syndrome, with the Rotterdam criteria being the most inclusive. Evidence suggests that polycystic ovary syndrome is signific...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2020.04.004
更新日期：2020-10-01 00:00:00
abstract：OBJECTIVE:The primary objective of this study was to identify specific educational goals for obstetrics and gynecology residents in the ambulatory setting. STUDY DESIGN:A cross-sectional study of current practice patterns in primary care, benign gynecology, and office procedures was performed with mailings to local pr...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2004.07.070
更新日期：2004-11-01 00:00:00
abstract：:Prospectively collected information on blood pressure and proteinuria was available for geographically defined populations of primigravidas in Burma, China, Thailand, and Viet Nam. Clinically recognized hypertension during pregnancy varied by a factor of 25 between countries, and even a strict definition of proteinuri...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1988-01-01 00:00:00
abstract：BACKGROUND:The health and economic benefits of paid parental leave have been well-documented. In 2016, the American College of Obstetricians and Gynecologists released a policy statement about recommended parental leave for trainees; however, data on adoption of said guidelines are nonexistent, and published data on pa...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2018.04.017
更新日期：2018-08-01 00:00:00
abstract：:The possibility of dispersing viral deoxyribonucleic acid during carbon dioxide laser treatment of human papillomavirus-containing genital infections has been investigated with a commercially available dot blot hybridization technique. The viral ribonucleic acid probes were specific for groups of human papillomavirus ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(90)90705-c
更新日期：1990-10-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to identify clinical signs and symptoms associated with detection of human papillomavirus (HPV) DNA in the female genital tract. STUDY DESIGN:A total of 516 university students (18 to 24 years old) enrolled in a cohort study that included the collection of genital specimens for ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1067/mob.2003.164
更新日期：2003-03-01 00:00:00
abstract：:The effects of acute methadone exposure on fetal behavioral activity were investigated in 10 unanesthetized fetal lamb preparations. Fetal behavioral activity was interpreted indirectly from the electrocorticogram (ECoG), electromyogram, electrooculogram, blood pressure, heart rate (FHR), and breathing movements (FBMs...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(83)91056-6
更新日期：1983-05-15 00:00:00
abstract：:Preterm birth remains a major cause of perinatal morbidity and mortality. A short cervix is strongly associated with spontaneous preterm birth. Professional organizations support cervical length screening for singleton gestations with a prior spontaneous preterm birth and second-trimester cervical length measurements ...
journal_title：American journal of obstetrics and gynecology
pub_type： 社论
doi：10.1016/j.ajog.2016.07.019
更新日期：2016-12-01 00:00:00
abstract：OBJECTIVE:Maternal serum placenta growth factor levels have been shown to be significantly reduced in women with established preeclampsia. However, the temporal change in serum placenta growth factor levels before the clinical onset of preeclampsia is not known. STUDY DESIGN:Serum samples were collected from patients ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1067/mob.2001.113129
更新日期：2001-05-01 00:00:00
abstract：:A chart for displaying neonatal survival data regarding low birth weight and early gestational age is presented. Survival data at two institutions for infants with low birth weight and early gestational age are compared. This format is useful for student and resident teaching, for counseling parents-to-be about potent...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(84)90026-7
更新日期：1984-07-01 00:00:00
abstract：:The results of predictive fertilization bioassays (hemizona assay, hamster ova-human sperm penetration assay), in vitro fertilization treatment, fertile donor cross-match tests with either sperm or oocytes, and oocyte micromanipulation for assisted fertilization were used to establish a pathophysiologic diagnosis in c...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(91)90684-j
更新日期：1991-05-01 00:00:00
abstract：:We describe the preparation and usage of positive and negative quality control standards for the proline aminopeptidase assay of vaginal secretions as an indicator of bacterial vaginosis. ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(89)80075-4
更新日期：1989-03-01 00:00:00
abstract：:SAA and SIA were assayed in the sera of 172 infertile couples and in the CM of the women and 18 control subjects. Complete infertility evaluation was performed in all subjects except the controls. Results of these studies were correlated with PCT's. Sperm antibodies were detected in the CM of 25.6% of infertile women ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：
更新日期：1980-04-01 00:00:00
abstract：OBJECTIVE:The purpose of this study was to describe trends and outcomes of planned births. STUDY DESIGN:Data from linked birth and hospital records for 779,521 singleton births at ≥33 weeks' gestation from 2001-2009 were used to determine trends in planned births (prelabor cesarean section and labor inductions). Adver...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2012.06.082
更新日期：2012-09-01 00:00:00
abstract：BACKGROUND:The integrity of the pelvic autonomic nervous system is essential for proper bowel, bladder, and sexual function. OBJECTIVE:The purpose of this study was to characterize the anatomic path of the pelvic autonomic system and to examine relationships to clinically useful landmarks. STUDY DESIGN:Detailed disse...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2016.12.002
更新日期：2017-04-01 00:00:00
abstract：OBJECTIVE:The study's objective was to provide an introduction to the role of corticotropin-releasing hormone in preterm delivery associated with stress. STUDY DESIGN:A selective review of the current literature relevant to the objective was undertaken. Published data were analyzed for relevance to the biochemical mod...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,评审
doi：10.1016/s0002-9378(99)70713-1
更新日期：1999-01-01 00:00:00
abstract：OBJECTIVE:The objective of the study was to determine whether transversus abdominis plane (TAP) block reduces postoperative pain when compared with trocar site infiltration of bupivacaine in gynecological laparoscopy. STUDY DESIGN:This was a prospective, randomized, double-blinded clinical trial using patients as thei...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajog.2014.07.049
更新日期：2015-02-01 00:00:00
abstract：:To evaluate whether mouthing movement in the human fetus is related to advance in gestational age and whether such movement is concurrent with rapid eye movement or non-rapid eye movement phases, 26 fetuses from 28 to 41 weeks' gestation were observed for 60 continuous minutes with real-time ultrasonography. It was ev...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(89)90517-6
更新日期：1989-08-01 00:00:00
abstract：OBJECTIVE:Our purpose was to quantitatively assess the effects of oxytocin on membrane properties in the pregnant human myometrium. STUDY DESIGN:Specimens were obtained from the lower uterine segment during cesarean section at term. Electrical activity was recorded from individual cells by a conventional microelectrod...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(97)70465-4
更新日期：1997-07-01 00:00:00
abstract：:Several copper and cupric ion sources were shown to kill or inhibit the growth of Neisseria gonorrhoeae in vitro. The media used was GC Agar Base supplemented with Isovitalex. Pure copper shot, cupric sulfate, and cupric chloride were used as copper sources. E. coli and Neisseria meningitis were used in addition to...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/0002-9378(73)90889-2
更新日期：1973-05-01 00:00:00
abstract：OBJECTIVE:We sought to determine if genetic polymorphisms in the aryl hydrocarbon receptor signaling pathway are associated with menopausal hot flashes via hormone levels. STUDY DESIGN:Women (n = 639) aged 45-54 years completed a study survey and provided blood for genetic and hormone analyses. The associations were a...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2012.05.019
更新日期：2012-09-01 00:00:00
abstract：:One hundred eighty-six patients with epithelial tumors of the ovary who were managed at the M. D. Anderson Hospital and Tumor Institute underwent an exploratory operation ("second-look" operation) to assess the status of the cancer. Fifty-eight patients were found to have no evidence of disease (NED) and chemotherapy ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(16)32778-8
更新日期：1980-12-15 00:00:00
abstract：OBJECTIVE:We sought to evaluate postsurgical adhesions in women of different races with or without keloids. STUDY DESIGN:This was a prospective study evaluating postsurgical adhesions after a cesarean delivery in 429 women with or without keloids. The outcome measures were the prevalence and extent of adhesions in wom...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/j.ajog.2010.09.005
更新日期：2011-02-01 00:00:00
abstract：BACKGROUND:Surgical site infections (SSIs) are an important cause of morbidity following cesarean delivery, particularly in obese patients. Methods to reduce SSIs after cesarean delivery would have an important impact in obese obstetric patients. OBJECTIVE:The purpose of this study was to determine whether the Alexis ...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章,随机对照试验
doi：10.1016/j.ajog.2015.09.096
更新日期：2016-02-01 00:00:00
abstract：:Clearance indices (clearance of experimental material: clearance of antipyrine, CI) across the perfused human placenta were determined for urea, sodium, and chloride. The selected materials are of relatively small molecular weight and are water soluble. Clearance of urea was determined under conditions of net transfer...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(15)33310-x
更新日期：1981-11-15 00:00:00
abstract：:Intravenous leiomyomatosis is a rare benign neoplasm that commonly grows into the pelvic veins and the inferior vena cava and, rarely, the right side of the heart. We report the first case of intravenous leiomyomatosis with cardiac involvement in a pregnant woman. The treatment of choice is surgical resection in two s...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(98)70453-3
更新日期：1998-03-01 00:00:00
abstract：:Reanalysis of data on the ovulation method of natural family planning collected by the World Health Organization yields the following conclusions. The method is effective during perfect (correct and consistent) use, with a first-year probability of failure of 3.4%. However, it is extremely unforgiving of imperfect use...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(11)90581-x
更新日期：1991-12-01 00:00:00
abstract：:Lidocaine was recently found to rapidly cross the placenta and result in considerable fetal exposure after local infiltration of the perineum for episiotomy. For this reason, a more appropriate agent for local perineal infiltration might be a drug with rapid metabolism and inactive metabolites. 2-Chloroprocaine, an es...
journal_title：American journal of obstetrics and gynecology
pub_type： 杂志文章
doi：10.1016/s0002-9378(87)80313-7
更新日期：1987-11-01 00:00:00
