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Diagnostic accuracy of guided cervical biopsies: a prospective multicenter study comparing the histopathology of simultaneous biopsy and cone specimen.

Abstract：

OBJECTIVE:We sought to determine the validity of colposcopically directed cervical biopsies as a diagnostic test to define the degree of cervical intraepithelial neoplasia (CIN). STUDY DESIGN:In a prospective multicenter trial, patients undergoing excisional procedures of the transformation zone additionally had colposcopy and up to 3 guided cervical biopsies in a single procedure. Cervical biopsies were regarded as a diagnostic test to detect high-grade lesions (CIN 2,3), with the cone specimen as reference standard. RESULTS:In all, 488 biopsies were performed in 244 cases, with 2 biopsies done in 192 cases. Cervical biopsies underestimated the severity of lesions in 46.7% of cases. Sensitivity, specificity, and positive and negative predictive values were 66.2% (95% confidence interval [CI], 59.4-72.3), 95.0% (95% CI, 83.5-98.6), 98.5% (95% CI, 94.8-99.6), and 35.5% (95% CI, 27.1-44.9), respectively. CONCLUSION:Our data suggest that cytologically suspected high-grade lesions (CIN 2,3) can be confirmed by biopsy in many cases, but they cannot be excluded.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Zuchna C,Hager M,Tringler B,Georgoulopoulos A,Ciresa-Koenig A,Volgger B,Widschwendter A,Staudach A

doi

10.1016/j.ajog.2010.05.033

subject

Has Abstract

pub_date

2010-10-01 00:00:00

pages

321.e1-6

issue

4

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(10)00676-9

journal_volume

203

pub_type

临床试验,杂志文章,多中心研究

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