Hydrops fetalis and stillbirth in a male glucose-6-phosphate dehydrogenase-deficient fetus possibly due to maternal ingestion of sulfisoxazole; a case report.

Abstract:

:A woman pregnant with her second child was given sulfisoxazole (Gantrisin) during her eighth month of pregnancy for a urinary tract infection. Her 34-week-old male infant was stillborn with hydrops fetalis and severe anemia. The mother was found to be glucose-6-phosphate-dehydrogenase (G-6-PDH) deficient. Ingestion of the drug which is known to produce hemolysis in G-6-PDH-deficient people may have compromised the male infant by creating an abundance of bilirubin via massive hemolysis and also retarding its elimnation by competing with bilirubin for albumin-binding sites. This case identifies a newly recognized danger in the use of sulfonzmides in the third trimester of pregnancy.

journal_name

Am J Obstet Gynecol

authors

Perkins RP

doi

10.1016/0002-9378(71)90781-2

subject

Has Abstract

pub_date

1971-10-01 00:00:00

pages

379-81

issue

3

eissn

0002-9378

issn

1097-6868

pii

0002-9378(71)90781-2

journal_volume

111

pub_type

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