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Interferon-gamma expression is an independent prognostic factor in ovarian cancer.

Abstract：

BACKGROUND:Epithelial ovarian cancer prognosis is improved by the presence of intratumoral CD3 + T cells, which are known to produce interferon-gamma. We therefore speculated that interferon-gamma expression in ovarian cancer-infiltrating T-lymphocytes might cause better prognosis. PATIENTS AND METHODS:Reverse transcriptase polymerase chain reaction was performed to measure the expression of interferon-gamma and other related genes in normal ovaries (n = 19) and in ovarian cancer specimens (n = 99). Median follow-up of patients was 5.8 years. RESULTS:Interferon-gamma and CD-3 expression did not significantly differ in normal and malignant tissue. Patients with high levels of interferon-gamma expression had significantly longer progression-free and overall survival. Median time to progression was 10 and 29 months for patients with low and high interferon-gamma expression, respectively ( P = .039). Corresponding survival times were 29 and 44 months ( P < .032). Application of multivariate Cox regression analysis showed interferon-gamma expression to be an independent prognostic factor for progression-free and overall survival. CONCLUSION:Elevated interferon-gamma expression correlates with improved clinical outcome in patients with ovarian cancer.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Marth C,Fiegl H,Zeimet AG,Müller-Holzner E,Deibl M,Doppler W,Daxenbichler G

doi

10.1016/j.ajog.2004.05.007

subject

Has Abstract

pub_date

2004-11-01 00:00:00

pages

1598-605

issue

5

eissn

0002-9378

issn

1097-6868

pii

S0002937804004764

journal_volume

191

pub_type

杂志文章

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