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Use of a new platelet function analyzer to detect von Willebrand disease in women with menorrhagia.

Abstract：

OBJECTIVE:The purpose of this study was to assess the usefulness of a new platelet function analyzer in the detection of von Willebrand disease and platelet dysfunction in women with menorrhagia. STUDY DESIGN:Women with menorrhagia and control subjects were tested with a platelet function analyzer. If the results were abnormal, further testing was performed for possible von Willebrand disease or platelet dysfunction. Results were compared. RESULTS:Of the 108 women with menorrhagia, 28 had an abnormal platelet function analysis results: 7 results were suggestive of von Willebrand disease; 17 results were suggestive of platelet dysfunction, and 4 results were inconclusive. Of the 100 control subjects, 18 subjects had an abnormal platelet function analysis result: 2 results were suggestive of von Willebrand disease; 12 results were suggestive of platelet dysfunction, and 4 results were inconclusive. The prevalence of suspected von Willebrand disease was 6% among women with menorrhagia and 2% among control subjects. Among white women, the prevalence was 10% compared with 1% among control subjects. CONCLUSION:We demonstrated that the platelet function analyzer could be used to detect von Willebrand disease in women with menorrhagia.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

James AH,Lukes AS,Brancazio LR,Thames E,Ortel TL

doi

10.1016/j.ajog.2004.03.009

subject

Has Abstract

pub_date

2004-08-01 00:00:00

pages

449-55

issue

2

eissn

0002-9378

issn

1097-6868

pii

S0002937804002388

journal_volume

191

pub_type

杂志文章

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