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Prenatal psychosocial stress exposure is associated with insulin resistance in young adults.

Abstract：

OBJECTIVE:The objective of the study was to examine the association in humans between maternal psychosocial stress exposure during pregnancy and measures of glucose-insulin metabolism in the adult offspring. STUDY DESIGN:Healthy young adults whose mothers experienced major stressful life events during their pregnancy (n = 36, prenatal stress, PS group, mean age 25 +/- 5.14 [SD] years) and a comparison group (n = 22, CG, mean age 24 +/- 3.7 [SD] years) underwent an oral glucose tolerance test. RESULTS:Glucose levels were not significantly different across the groups; however, prenatally stressed subjects showed significantly elevated 2-hour insulin (P = .01) and C-peptide levels (P = .03). These differences were independent of other major risk factors for insulin resistance, including birth phenotype (birthweight, length of gestation), a family history of diabetes, gestational diabetes, body mass index, proinflammatory state, and smoking. CONCLUSION:Higher insulin responses reflect relative insulin resistance in these prenatally stressed young adults. This study is the first to provide evidence for a link in humans between prenatal psychosocial stress exposure and alterations in glucose-insulin metabolic function.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Entringer S,Wüst S,Kumsta R,Layes IM,Nelson EL,Hellhammer DH,Wadhwa PD

doi

10.1016/j.ajog.2008.03.006

subject

Has Abstract

pub_date

2008-11-01 00:00:00

pages

498.e1-7

issue

5

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(08)00267-6

journal_volume

199

pub_type

杂志文章

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