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Effects of terbutaline sulfate on fetal cardiac function.

Abstract：

:An isolated heart preparation was used to study the effects of terbutaline sulfate (Brethine) on fetal cardiac function. Pregnant guinea pigs received daily subcutaneous injections of terbutaline for 10 day, whereas a control group received placebo injections. Fetal guinea pig hearts were evaluated for cariodynamic and pathologic differences. Fetuses exposed to terbutaline demonstrated a higher mean heart rate (p less than 0.01), a higher mean heart weight (p less than 0.05), a higher mean heart weight/body weight ratio (p less than 0.01), and a trend toward higher left ventricular systolic pressure levels (p less than 0.1). These hemodynamic responses in fetuses exposed to terbutaline may result in increased functional demands that may predispose myocardial tissue to damage.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Petersen R,Carter LS,Chescheir NC,Katz VL,Cefalo RC

doi

10.1016/0002-9378(89)90346-3

subject

Has Abstract

pub_date

1989-09-01 00:00:00

pages

509-12

issue

3

eissn

0002-9378

issn

1097-6868

pii

0002-9378(89)90346-3

journal_volume

161

pub_type

杂志文章

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