当前位置： SCI文献检索 > AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY期刊下所有文献 > Reduced endothelial nitric oxide synthase activity and concentration in fetal umbilical veins from maternal cigarette smokers.

Reduced endothelial nitric oxide synthase activity and concentration in fetal umbilical veins from maternal cigarette smokers.

Abstract：

OBJECTIVE:This study aimed to investigate the effect of maternal cigarette smoking on endothelial nitric oxide synthase (eNOS) activity and concentration in the fetal umbilical vein, and subsequently, to relate the findings to the size of the newborn. STUDY DESIGN:Forty-four nonsmoking and 30 smoking women were included in the study. Umbilical vein endothelial cells were isolated immediately after delivery. The eNOS activity was determined in the samples by the conversion of (14)C-L-arginine to (14)C-L-citrulline, and the eNOS concentration was determined by a human eNOS immunoassay. RESULTS:Newborns of smokers had a lower weight (P=.014) and a smaller head circumference (P=.002) than those newborns of nonsmokers. The eNOS activity in fetal umbilical veins exposed to maternal smoking was 40% lower (P=.006), and the eNOS concentration 32% lower (P=.053) in newborns of smokers than in nonsmokers. CONCLUSION:The findings suggest that maternal smoking reduces nitric oxide production in the fetal circulation. This may contribute to retarded fetal growth caused by the subsequent endothelial dysfunction with reduction of dilatory capacity of the vessels.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Andersen MR,Walker LR,Stender S

doi

10.1016/j.ajog.2003.12.040

subject

Has Abstract

pub_date

2004-07-01 00:00:00

pages

346-51

issue

1

eissn

0002-9378

issn

1097-6868

pii

S0002937804000183

journal_volume

191

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY文献大全
  • Conservative conization for microinvasive carcinoma of the cervix.

    abstract：OBJECTIVE:Our purpose was to examine conservative conization as treatment for microinvasive carcinoma of the cervix with depth of invasion < 3 mm. STUDY DESIGN:Twelve patients with microinvasive carcinoma of the cervix underwent cervical conization under colposcopic guidance followed by careful observation. RESULTS:T...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(97)70394-6

    authors： Tseng CJ,Horng SG,Soong YK,Hsueh S,Hsieh CH,Lin HW

    更新日期：1997-05-01 00:00:00

  • Classification of human fetal movement.

    abstract：:A study of fetal activity was undertaken as the first step in a series of physiologic fetal movement studies. A simple, safe, noninvasive, clinically applicable method for studying fetal movement with a tocodynamometer is described. Four basic types of fetal movement have been seen and defined in terms of their durati...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(76)90467-1

    authors： Timor-Tritsch I,Zador I,Hertz RH,Rosen MG

    更新日期：1976-09-01 00:00:00

  • Risk factors for maternal and fetal outcome in pregnancy complicated by Ebstein anomaly.

    abstract：OBJECTIVE:The goal of the study was to examine risks in pregnancy in patients with Ebstein anomaly. STUDY DESIGN:Data were examined retrospectively for 13 patients (27 pregnancies, 21 live births) with Ebstein anomaly during pregnancy who were treated at our institution from 1985 to 2011. The associated anomalies in t...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2013.07.005

    authors： Katsuragi S,Kamiya C,Yamanaka K,Neki R,Miyoshi T,Iwanaga N,Horiuchi C,Tanaka H,Yoshimatsu J,Niwa K,Ikeda T

    更新日期：2013-11-01 00:00:00

  • Antibodies to Chlamydia trachomatis and risk for tubal pregnancy.

    abstract：:We performed a case-control study of the effect of exposure to Chlamydia trachomatis on the risk for tubal pregnancy. Sixty women with tubal pregnancies and 60 matched control women with normal second-trimester intrauterine pregnancies were studied. Cases were more likely than controls to have detectable antichlamydia...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(88)80177-7

    authors： Walters MD,Eddy CA,Gibbs RS,Schachter J,Holden AE,Pauerstein CJ

    更新日期：1988-10-01 00:00:00

  • Cardiovascular risk and combined oral contraceptives: clinical decisions in settings of uncertainty.

    abstract：:Although generally safe, combined oral contraceptives (COCs) are associated with risks, including an estimated 2-fold increased relative risk of cardiovascular events. For most women taking COCs for contraception, absolute cardiovascular risks are very low, and the overall risks of COCs are outweighed by the risks of ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2012.01.037

    authors： Beller JP,McCartney CR

    更新日期：2013-01-01 00:00:00

  • Antepartum fetal heart rate variability and intervillous placental blood flow in association with smoking.

    abstract：:Intervillous placental blood flow and indices of fetal heart rate variability were measured from seven healthy pregnant women in the last trimester of pregnancy, once before and twice after smoking one cigarette. A blood flow reduction was observed in seven, a rise in five, and no change in two measurements. When inte...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(83)90975-4

    authors： Rauramo I,Forss M,Kariniemi V,Lehtovirta P

    更新日期：1983-08-15 00:00:00

  • Is maternal posturing during labor efficient in preventing persistent occiput posterior position? A randomized controlled trial.

    abstract：OBJECTIVE:We sought to evaluate the efficacy of maternal posturing during labor on the prevention of persistent occiput posterior (OP) position. STUDY DESIGN:We conducted a randomized trial including 220 patients in labor with a single fetus in documented OP position. Main outcome was the proportion of anterior rotati...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ajog.2012.10.882

    authors： Desbriere R,Blanc J,Le Dû R,Renner JP,Carcopino X,Loundou A,d'Ercole C

    更新日期：2013-01-01 00:00:00

  • Current practices in the prediction and prevention of preterm birth in patients with higher-order multiple gestations.

    abstract：OBJECTIVE:We sought to determine the interventions utilized by maternal-fetal medicine specialists in the prediction and prevention of preterm labor in higher-order multiple (HOM) gestations. STUDY DESIGN:Online questionnaires and email surveys were sent to all the maternal-fetal medicine specialists in Canada (n=122)...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2014.12.031

    authors： Baker E,Hunter T,Okun N,Farine D

    更新日期：2015-05-01 00:00:00

  • Severe obstructive sleep apnea and associated snoring documented during external tocography.

    abstract：:Severe obstructive sleep apnea, a disturbance of sleep resulting from intermittent periodic obstruction of the upper airway, was diagnosed after cardiotocography during which the external tocodynamometer disclosed a pattern initially thought to represent uterine activity. In spite of this obstructive sleep apnea with ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(91)90354-t

    authors： Sherer DM,Caverly CB,Abramowicz JS

    更新日期：1991-11-01 00:00:00

  • Bacterial colonization of the vagina during pregnancy in four ethnic groups. Vaginal Infections and Prematurity Study Group.

    abstract：OBJECTIVE:Our purpose was determine whether there are ethnic differences in vaginal colonization with organisms reputed to be associated with preterm delivery. STUDY DESIGN:In seven urban medical centers in the United States from 1984 to 1989, 13,747 predominantly low-socioeconomic-status women at 23 to 26 weeks' gest...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(96)70617-8

    authors： Goldenberg RL,Klebanoff MA,Nugent R,Krohn MA,Hillier S,Andrews WW

    更新日期：1996-05-01 00:00:00

  • Severity of pelvic inflammatory disease as a predictor of the probability of live birth.

    abstract：OBJECTIVE:Our aim was to study the association between severity of pelvic inflammatory disease at laparoscopy and the probability of achieving a live birth, while accounting for subsequent episodes of pelvic inflammatory disease. STUDY DESIGN:Beginning in 1960 a cohort of 1288 women in Lund, Sweden, who had clinical s...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(98)70534-4

    authors： Lepine LA,Hillis SD,Marchbanks PA,Joesoef MR,Peterson HB,Westrom L

    更新日期：1998-05-01 00:00:00

  • Ethnic differences at risk for gestational trophoblastic disease in New Mexico: A 25-year population-based study.

    abstract：OBJECTIVE:The purpose of this study was to compare gestational trophoblastic disease incidence rates with the use of population-based data. STUDY DESIGN:All incident cases between 1973 and 1997 and live birth, pregnancy, and women at risk were tabulated with the use of data that were derived from the New Mexico Tumor ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2003.39

    authors： Smith HO,Hilgers RD,Bedrick EJ,Qualls CR,Wiggins CL,Rayburn WF,Waxman AG,Stephens ND,Cole LW,Swanson M,Key CR

    更新日期：2003-02-01 00:00:00

  • Electronic fetal heart monitoring, auscultation, and neonatal outcome.

    abstract：:In a large randomized, controlled study of fetal heart rate monitoring with either continuous electronic fetal heart monitoring or auscultation at specified intervals, only one pattern of deviation in the fetal heart rate correlated significantly with neonatal neurologic examinations at 0 to 48 hours and 72 hours to 1...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-9378(91)90700-2

    authors： Ellison PH,Foster M,Sheridan-Pereira M,MacDonald D

    更新日期：1991-05-01 00:00:00

  • Psychological correlates of differential infertility diagnosis in an in vitro fertilization program.

    abstract：:We describe a study designed to assess the role of infertility diagnosis in differentiating participants in an in vitro fertilization program on psychological variables. Three hundred forty-eight in vitro fertilization candidates representative of five diagnostic categories (tubal problems, endometriosis, male factor,...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(88)90229-3

    authors： Shatford LA,Hearn MT,Yuzpe AA,Brown SE,Casper RF

    更新日期：1988-05-01 00:00:00

  • Role of plasma lipoproteins in the pathogenesis of atherosclerotic disease, with special reference to sex hormone effects.

    abstract：:Plasma lipoproteins constitute a complex lipid transport system. Very low-density lipoproteins transport triglycerides to peripheral tissues, whereas low-density lipoproteins are the main carriers of cholesterol. Cholesterol transport in low-density lipoprotein enters body cells by way of "low-density lipoprotein rece...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/0002-9378(90)90571-n

    authors： Tikkanen MJ

    更新日期：1990-07-01 00:00:00

  • Over-screening for chlamydia and gonorrhea among urban women age ≥25 years.

    abstract：OBJECTIVE:The purpose of this study was to determine the prevalence of Chlamydia trachomatis (CT) and Neisseria gonorrhoeae (NG) in older women who are at increased risk of sexually transmitted infections (STIs) based on community STI prevalence. Additionally, we explored the associations between STI risk factors and C...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2014.06.051

    authors： Jackson JA,McNair TS,Coleman JS

    更新日期：2015-01-01 00:00:00

  • Change in serum beta-human chorionic gonadotropin after abortion with methotrexate and misoprostol.

    abstract：OBJECTIVE:The purpose of this study was to determine the normal beta-human chorionic gonadotropin change within 24 hours after a medical abortion. Because a medical abortion creates a "miscarriage," these data can represent the serum beta-human chorionic gonadotropin changes that would occur with a complete spontaneous...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/s0002-9378(96)70463-5

    authors： Creinin MD

    更新日期：1996-02-01 00:00:00

  • The correlation of biochemical monitoring versus umbilical flow velocity measurements of the human fetus.

    abstract：:The pulsatility index of the fetal umbilical arteries was evaluated in 14 high-risk pregnant patients delivered by cesarean section between 30 and 35 weeks of gestation. Transabdominal cord sampling by ultrasonic guidance was performed on 10 of these patients. Umbilical arterial and venous blood was obtained in all pa...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(88)90418-8

    authors： Ferrazzi E,Pardi G,Bauscaglia M,Marconi AM,Gementi B,Bellotti M,Makowski EL,Battaglia FC

    更新日期：1988-11-01 00:00:00

  • Treatment of menopausal hot flashes with transdermal administration of clonidine.

    abstract：:A randomized prospective double-blind study was performed to evaluate the efficacy of a transdermal therapeutic system delivering clonidine in the treatment of menopausal hot flashes. Frequency, severity and duration of the flushing attacks before and during the 8-week treatment period were evaluated. The reduction in...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：10.1016/0002-9378(87)90050-0

    authors： Nagamani M,Kelver ME,Smith ER

    更新日期：1987-03-01 00:00:00

  • The relationship between perineal cosmetic talc usage and ovarian talc particle burden.

    abstract：OBJECTIVE:Epidemiologic studies support the hypothesis of a dose-related risk of epithelial ovarian cancer with perineal talc usage exposure. Frequency and duration of talc has not been previously correlated with ovarian talc content. STUDY DESIGN:Ovaries were studied from 24 women undergoing incidental oophorectomy w...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(96)70597-5

    authors： Heller DS,Westhoff C,Gordon RE,Katz N

    更新日期：1996-05-01 00:00:00

  • Diagnostic accuracy of fetal choroid plexus length to head biometry ratio at 11 to 13 weeks for open spina bifida.

    abstract：BACKGROUND:Open spina bifida is a major congenital anomaly with an estimated incidence of <1 in 1000. The diagnosis of open spina bifida is usually made during the second trimester, but first-trimester detection rate of spina bifida is increasingly reported. Recently, the mean choroid plexus length to occipitofrontal d...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2020.08.058

    authors： Kalafat E,Ting L,Thilaganathan B,Papageorghiou AT,Khalil A

    更新日期：2020-08-22 00:00:00

  • Antepartum chronic fetal vesicoamniotic shunts for obstructive uropathy: A report of two cases.

    abstract：:Two fetuses with obstructive uropathy characterized by striking oligohydramnios and dilatation of the urinary collecting system were identified by ultrasound and treated by percutaneous insertion of a long-term vesicoamniotic silicone rubber shunt. Both fetuses were less than 16 weeks' gestation at diagnosis and less ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(83)90685-3

    authors： Manning FA,Harman CR,Lange IR,Brown R,Decter A,MacDonald N

    更新日期：1983-04-01 00:00:00

  • Vaginal birth after cesarean section: trial of labor or repeat cesarean section? A decision analysis.

    abstract：OBJECTIVE:The risk of perinatal death associated with labor after previous cesarean section appears higher than with a repeated cesarean section. On the other hand, repeated cesarean sections are associated with increased maternal morbidity and mortality from placental pathologic conditions (previa or accreta) on subse...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/s0002-9378(03)00833-0

    authors： Mankuta DD,Leshno MM,Menasche MM,Brezis MM

    更新日期：2003-09-01 00:00:00

  • Global placental gene expression in gestational diabetes mellitus.

    abstract：OBJECTIVE:Gestational diabetes mellitus (GDM) is thought to modify the pattern of placental transcriptome. In a microarray study and a confirmatory quantitative real-time reverse transcription-polymerase chain reaction study, we investigated global placental gene expression in GDM. STUDY DESIGN:Ribonucleic acid was ex...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2008.08.022

    authors： Enquobahrie DA,Williams MA,Qiu C,Meller M,Sorensen TK

    更新日期：2009-02-01 00:00:00

  • The association of cerebral palsy and death with small-for-gestational-age birthweight in preterm neonates by individualized and population-based percentiles.

    abstract：OBJECTIVE:The objective of the study was to determine whether an individualized growth standard (IS) improves the identification of preterm small-for-gestational-age (SGA) neonates at risk of developing moderate/severe cerebral palsy (CP) or death. STUDY DESIGN:This study was a secondary analysis of data from a random...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2013.06.007

    authors： Grobman WA,Lai Y,Rouse DJ,Spong CY,Varner MW,Mercer BM,Leveno KJ,Iams JD,Wapner RJ,Sorokin Y,Thorp JM Jr,Ramin SM,Malone FD,O'Sullivan MJ,Hankins GD,Caritis SN,Eunice Kennedy Shriver National Institute of Child Health and

    更新日期：2013-10-01 00:00:00

  • Evaluation of a clinical skills orientation program for residents.

    abstract：OBJECTIVE:Our purpose was to implement and evaluate an orientation program for residents, focusing on outpatient clinical skills. STUDY DESIGN:Eleven of 12 residents participated in a clinical skills orientation program immediately preceding the academic year. The skill stations included evaluation of abnormal uterine...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/s0002-9378(03)00624-0

    authors： Nielsen PE,Holland RH,Foglia LM

    更新日期：2003-09-01 00:00:00

  • To the Point: a prescription for well-being in medical education.

    abstract：:This article is from the "To The Point" series prepared by the Association of Professors of Gynecology and Obstetrics Undergraduate Medical Education Committee. The purpose of this review was to provide an overview of the importance of well-being in medical education. A literature search was performed by a Reference L...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ajog.2019.05.012

    authors： Hopkins L,Morgan H,Buery-Joyner SD,Craig LB,Everett EN,Forstein DA,Graziano SC,Hampton BS,McKenzie ML,Page-Ramsey SM,Pradhan A,Bliss S,Undergraduate Medical Education Committee, Association of Professors of Gynecology and Obstetr

    更新日期：2019-12-01 00:00:00

  • Where to look for the sentinel lymph node in cervical cancer.

    abstract：OBJECTIVE:The aim of this study was to analyze lymphatic spread to pelvic, parametrial, and paraaortic lymph nodes in patients with cervical cancer. STUDY DESIGN:We reviewed 619 patients with invasive cervical cancer treated by radical abdominal hysterectomy and systematic pelvic or pelvic and paraaortic lymphadenecto...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2007.09.053

    authors： Bader AA,Winter R,Haas J,Tamussino KF

    更新日期：2007-12-01 00:00:00

  • Vasodilatory response of fetoplacental vasculature to adrenomedullin after constriction with the thromboxane sympathomimetic U46619.

    abstract：OBJECTIVE:This study was undertaken to determine whether adrenomedullin, a hypotensive peptide, decreases vasomotor tone in fetoplacental vasculature that has been constricted with the thromboxane sympathomimetic U46619. STUDY DESIGN:The fetoplacental vascular beds of 20 perfused human placental cotyledons were vasoco...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2000.108071

    authors： Hoeldtke NJ,Wagner RK,Calhoun BC,Hume RF Jr

    更新日期：2000-12-01 00:00:00

  • Oxygen consumption in fetal lambs after maternal administration of sodium pentobarbital.

    abstract：:To determine whether anesthesia lowers fetal oxygen consumption, sodium pentobarbital (10 mg/kg) was given intravenously to seven chronically instrumented pregnant ewes (123 to 144 days' gestation). Oxygen consumption fell by 23% in association with a rise in fetal vascular PO2. Fetal breathing movements were abolishe...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(86)90628-9

    authors： Rurak DW,Taylor SM

    更新日期：1986-03-01 00:00:00