The Preterm Prediction Study: association of second-trimester genitourinary chlamydia infection with subsequent spontaneous preterm birth.

Abstract:

OBJECTIVE:This study was undertaken to determine the association between genitourinary tract infection with Chlamydia trachomatis and spontaneous preterm birth. STUDY DESIGN:Genitourinary tract infection with C trachomatis was determined with a ligase chain reaction assay of voided urine samples collected at 24 weeks' gestation (22 weeks' to 24 weeks 6 days' gestation) and 28 weeks' gestation (27 weeks' to 28 weeks 6 days' gestation). Case patients (spontaneous preterm birth at <37 weeks' gestation; n = 190) and control subjects (delivery at >/=37 weeks' gestation, matched for race, parity, and center; n = 190) were selected from 2929 women enrolled in the Preterm Prediction Study of the National Institute of Child Health and Human Development Maternal-Fetal Medicine Units Network. RESULTS:Genitourinary C trachomatis infection (11% overall) was significantly more common among the case patients than among the control subjects at 24 weeks' gestation (15.8% vs 6.3%; P =.003) but not at 28 weeks' gestation (12.6% vs 10.9%; P =.61). Women with chlamydia infection were more likely to have bacterial vaginosis (57.1% vs 32.9%; P =.002) and a short cervical length (

journal_name

Am J Obstet Gynecol

authors

Andrews WW,Goldenberg RL,Mercer B,Iams J,Meis P,Moawad A,Das A,Vandorsten JP,Caritis SN,Thurnau G,Miodovnik M,Roberts J,McNellis D

doi

10.1067/mob.2000.106556

subject

Has Abstract

pub_date

2000-09-01 00:00:00

pages

662-8

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(00)33419-6

journal_volume

183

pub_type

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