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An Australian twin study of the genetic basis of preeclampsia and eclampsia.

Abstract：

OBJECTIVE:We investigated maternal versus fetal genetic causes of preeclampsia and eclampsia by assessing concordance between monozygotic and dizygotic female co-twins, between female partners of male monozygotic and dizygotic twin pairs, and between female twins and partners of their male co-twins in dizygotic opposite-sex pairs. STUDY DESIGN:Two large birth cohorts of volunteer Australian female twin pairs (N = 1504 pairs and N = 858 pairs) were screened and interviewed, and available medical and hospital records were obtained and reviewed where indicated, with diagnoses assigned according to predetermined criteria. RESULTS:With strict diagnostic criteria used for preeclampsia and eclampsia, no concordant female twin pairs were found. Collapsing diagnoses of definite, probable, or possible preeclampsia or eclampsia resulted in very low genetic recurrence risk estimates. CONCLUSION:Results from these two cohorts of female twin pairs do not support clear, solely maternal genetic influences on preeclampsia and eclampsia. Numbers of parous female partners of male twins were too low for conclusions to be drawn regarding paternal transmission.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Treloar SA,Cooper DW,Brennecke SP,Grehan MM,Martin NG

doi

10.1067/mob.2001.109400

subject

Has Abstract

pub_date

2001-02-01 00:00:00

pages

374-81

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(01)65953-2

journal_volume

184

pub_type

杂志文章

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