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Progesterone receptor polymorphisms and clinical response to 17-alpha-hydroxyprogesterone caproate.

Abstract：

OBJECTIVE:Seventeen-alpha-hydroxyprogesterone caproate (17-OHPC) reduces recurrent preterm birth (PTB). We hypothesized that single nucleotide polymorphisms in the human progesterone receptor (PGR) affect response to 17-OHPC in the prevention of recurrent PTB. STUDY DESIGN:We conducted secondary analysis of a study of 17-OHPC vs placebo for recurrent PTB prevention. Twenty PGR gene single nucleotide polymorphisms were studied. Multivariable logistic regression assessed for an interaction between PGR genotype and treatment status in modulating the risk of recurrent PTB. RESULTS:A total of 380 women were included; 253 (66.6%) received 17-OHPC and 127 (33.4%) received placebo. In all, 61.1% of women were African American. Multivariable logistic regression demonstrated significant treatment-genotype interactions (either a beneficial or harmful treatment response) for African Americans delivering<37 weeks' gestation for rs471767 and rs578029, and for Hispanics/Caucasians delivering<37 weeks' gestation for rs500760 and <32 weeks' gestation for rs578029, rs503362, and rs666553. CONCLUSION:The clinical efficacy and safety of 17-OHPC for recurrent PTB prevention may be altered by PGR gene polymorphisms.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Manuck TA,Lai Y,Meis PJ,Dombrowski MP,Sibai B,Spong CY,Rouse DJ,Durnwald CP,Caritis SN,Wapner RJ,Mercer BM,Ramin SM

doi

10.1016/j.ajog.2011.03.048

subject

Has Abstract

pub_date

2011-08-01 00:00:00

pages

135.e1-9

issue

2

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(11)00436-4

journal_volume

205

pub_type

杂志文章,多中心研究,随机对照试验

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