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Hereditary thrombophilia and recurrence of ischemic placental disease.

Abstract：

OBJECTIVE:We sought to evaluate whether testing for hereditary thrombophilia alone or in combination with second-trimester uterine artery Doppler (UAD) is useful in predicting recurrent complications in patients with previous preeclampsia, placental abruption, or stillbirth. STUDY DESIGN:Between 2001 and 2005, 110 consecutive women were included in the study and received 100 mg of aspirin daily. Adjustment was made for several maternal confounding factors using a logistic regression model. RESULTS:After multivariable logistic regression analyses, only abnormal UAD assessment was significantly associated with recurrent complications (odds ratio, 11.2; 95% confidence interval, 3.8-32.6) Combining the results of UAD and the presence of laboratory markers of thrombophilia failed to improve the accuracy of UAD to predict recurrent complications. CONCLUSION:Hereditary thrombophilia testing is not useful in predicting recurrent complications in subsequent pregnancy.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Verspyck E,Borg JY,Roman H,Thobois B,Pia P,Marpeau L

doi

10.1016/j.ajog.2009.08.019

subject

Has Abstract

pub_date

2010-01-01 00:00:00

pages

54.e1-5

issue

1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(09)00944-2

journal_volume

202

pub_type

杂志文章,多中心研究

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