Abstract:
OBJECTIVE:Heritable thrombophilias have been implicated as a potential cause of abruption by vascular disruption at the uteroplacental interface. Polymorphisms of the methylenetetrahydrofolate reductase (MTHFR) gene have been linked to vascular complications outside of pregnancy, which includes stroke. Given the underlying thrombotic nature of abruption, we hypothesized that polymorphisms in the MTHFR gene are associated with abruption. STUDY DESIGN:We examined 2 variants in MTHFR: 677C-->T and 1298A-->C in genomic DNA extracted from maternal blood from the New Jersey-Placental Abruption Study, an ongoing, multicenter case-controlled study. We identified 195 women with a clinical diagnosis of abruption (cases) and 189 control subjects who were matched on race/ethnicity and parity. We assessed allele and genotype frequencies and their associations with abruption risk after adjusting for confounders through multivariable logistic regression analysis. RESULTS:The wild-type allele (C) frequency of the 677C-->T variant of MTHFR among cases and control subjects was 69.0% and 64.3%, respectively; the wild-type allele (A) of the 1298A-->C variant was 75.9% and 79.4%, respectively. Distributions of the 677C-->T alleles among control subjects violated the Hardy-Weinberg equilibrium (P = .007); distributions of the 1298A-->C alleles were in equilibrium (P = .825). In comparison to the wild-type genotype (C/C), the homozygous mutant form (T/T) of 677C-->T was not associated with abruption (odds ratio, 0.60; 95% confidence interval [CI], 0.33-1.18). Similarly, the homozygous mutant form (C/C) of the 1298A-->C polymorphism was distributed equally between cases and control subjects (odds ratio, 2.28; 95% CI, 0.82-6.35). Plasma homocysteine and vitamin B12, but not folate, concentrations were elevated in cases compared with control subjects among women with the wild-type genotype of MTHFR 677C-->T (P = .039 for homocysteine; P = .048 for B12; P = .224 for folate). CONCLUSION:In this population, neither heterozygosity nor homozygosity for the 677C-->T and 1298A-->C variants in MTHFR was associated with placental abruption.
journal_name
Am J Obstet Gynecoljournal_title
American journal of obstetrics and gynecologyauthors
Ananth CV,Peltier MR,De Marco C,Elsasser DA,Getahun D,Rozen R,Smulian JC,New Jersey-Placental Abruption Study Investigators.doi
10.1016/j.ajog.2007.06.046subject
Has Abstractpub_date
2007-10-01 00:00:00pages
385.e1-7issue
4eissn
0002-9378issn
1097-6868pii
S0002-9378(07)00822-8journal_volume
197pub_type
杂志文章,多中心研究abstract:OBJECTIVE:Our purpose was to determine the rates of recurrence, persistence, and progression of cervical intraepithelial neoplasia in women who were seropositive for human immunodeficiency virus after excisional therapy with and without highly active antiretroviral therapy. STUDY DESIGN:The records of 118 women with c...
journal_title:American journal of obstetrics and gynecology
pub_type: 杂志文章
doi:10.1067/mob.2001.111103
更新日期:2001-03-01 00:00:00
abstract::This study examines some potential factors that are associated with occasional readmission soon after discharge for laparoscopic sterilization--a generally innocuous outpatient procedure. Thirty-six early readmissions among 22,000 cases of laparoscopic sterilization (an incidence rate of 1.6 per 1,000 procedures) in a...
journal_title:American journal of obstetrics and gynecology
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journal_title:American journal of obstetrics and gynecology
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doi:10.1067/mob.2002.122417
更新日期:2002-07-01 00:00:00
abstract:OBJECTIVES:Review publications that significantly impacted on the knowledge of bacterial vaginosis. STUDY DESIGN:Assessment of information on the epidemiology, bacteriology, and pathology of bacterial vaginosis. RESULTS:Bacterial vaginosis has a complex microbiology. Further information is required on the epidemiolog...
journal_title:American journal of obstetrics and gynecology
pub_type: 历史文章,杂志文章,评审
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更新日期:1993-08-01 00:00:00
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journal_title:American journal of obstetrics and gynecology
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journal_title:American journal of obstetrics and gynecology
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更新日期:2009-02-01 00:00:00
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journal_title:American journal of obstetrics and gynecology
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abstract::Tissue deficiency of folic acid, as measured by a red cell folate level below 150 ng. per milliliter, was present in 16 per cent of 110 sequential pregnant women at the time of their first prenatal visit to a municipal clinic. A further 14 per cent of subjects had red cell folate levels in the range "suggestive but no...
journal_title:American journal of obstetrics and gynecology
pub_type: 杂志文章
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更新日期:1975-09-15 00:00:00
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更新日期:2013-11-01 00:00:00
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doi:10.1016/0002-9378(94)90154-6
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journal_title:American journal of obstetrics and gynecology
pub_type: 杂志文章
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更新日期:1987-09-01 00:00:00
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journal_title:American journal of obstetrics and gynecology
pub_type: 杂志文章
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更新日期:1999-12-01 00:00:00
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journal_title:American journal of obstetrics and gynecology
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更新日期:1995-02-01 00:00:00
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journal_title:American journal of obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/j.ajog.2007.04.045
更新日期:2007-08-01 00:00:00
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journal_title:American journal of obstetrics and gynecology
pub_type: 杂志文章
doi:10.1016/j.ajog.2004.03.009
更新日期:2004-08-01 00:00:00
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pub_type: 杂志文章
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journal_title:American journal of obstetrics and gynecology
pub_type: 杂志文章
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pub_type: 杂志文章
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更新日期:2012-07-01 00:00:00
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更新日期:2005-05-01 00:00:00
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pub_type: 杂志文章
doi:10.1016/j.ajog.2008.03.006
更新日期:2008-11-01 00:00:00
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journal_title:American journal of obstetrics and gynecology
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更新日期:1995-04-01 00:00:00
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更新日期:2016-09-01 00:00:00
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pub_type: 杂志文章
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更新日期:1976-07-01 00:00:00
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pub_type: 杂志文章,meta分析
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更新日期:2006-10-01 00:00:00