当前位置： SCI文献检索 > AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY期刊下所有文献 > The fetoplacental pressor effects of low-dose acetylsalicylic acid and angiotensin II in the ex vivo cotyledon model.

The fetoplacental pressor effects of low-dose acetylsalicylic acid and angiotensin II in the ex vivo cotyledon model.

Abstract：

OBJECTIVE:Our purpose was to investigate perfusion pressure changes ex vivo induced by angiotensin II on fetoplacental vasculature pretreated with low-dose acetylsalicylic acid. STUDY DESIGN:Two cotyledons from each of 12 placentas were perfused. The intervillous space of one cotyledon was infused with acetylsalicylic acid (5 x 10(-5) mol/L) similar to the serum concentration of women receiving daily low-dose aspirin therapy (60 to 81 mg). The control cotyledon was infused with an equivalent amount of normal saline solution. Two doses of angiotensin II, 1 x 10(-11.5) and 1 x 10(-10) moles, were injected as boluses into the chorionic arteries of each cotyledon. A 3 x 10(-7) mole dose of angiotensin II was also injected into the intervillous space. Statistical analysis was performed with analysis of variance, and results are expressed as mean pressure change in millimeters of mercury +/- SEM. RESULTS:Perfusion pressure response did not vary between cotyledons pretreated with acetylsalicylic acid and control cotyledons when 3 x 10(-7) moles of angiotensin II was injected into the intervillous space (8.0 +/- 1.9 mm Hg vs 9.8 +/- 1.6 mm Hg, p = 0.59). There were no differences between cotyledons in pressure response to 1 x 10(-11.5) moles of angiotensin II injected into the fetal circuit (5.9 +/- 0.8 mm Hg vs 6.7 +/- 0.9 mm Hg, p = 0.51). However, in the cotyledons pretreated with acetylsalicylic acid there was a decrease in the pressor response to 1 x 10(-10) moles of angiotensin II (14.1 +/- 1.4 mm Hg vs 21.5 +/- 3.3 mm Hg, p = 0.05). CONCLUSIONS:Low-dose aspirin infused into the intervillous space decreases vasoconstriction elicited by angiotensin II in the fetoplacental compartment. This suggests that maternal low-dose aspirin therapy has effects in the fetoplacental circulation in addition to its effects in the maternal circulation.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Napolitano PG,Hoeldtke NJ,Moore KH,Calhoun BC,Christensen ED,Markenson GR,Hume RF Jr

doi

10.1016/s0002-9378(97)70021-8

subject

Has Abstract

pub_date

1997-11-01 00:00:00

pages

1093-6

issue

5

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(97)70021-8

journal_volume

177

pub_type

杂志文章

相关文献

AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY文献大全
  • Microbiologic techniques for the diagnosis of pelvic inflammatory disease in developing countries.

    abstract：:Pelvic inflammatory disease is a major medical problem that causes serious complications in a large number of the female population in many developing countries. It is estimated that between 20% and 30% of gynecologic admissions in these countries are due to PID. The alarmingly high prevalence of gonorrhea is probably...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/0002-9378(80)91114-x

    authors： Osoba AO

    更新日期：1980-12-01 00:00:00

  • Sonar biparietal diameter. II. Predictive of three fetal growth patterns leading to a closer assessment of gestational age and neonatal weight.

    abstract：:Serial BPD readings were obtained from 142 normal parturients, with established dates, between 20 to 40 weeks of pregnancy. It is noted that fetal BPD's can be separated into one of three percentile rankings: large (i.e. above the seventy-fifth percentile), average (i.e. twenty-fifth to seventy-fifth percentile), and ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：

    authors： Sabbagha RE,Barton BA,Barton FB,Kingas E,Turner JH

    更新日期：1976-10-15 00:00:00

  • Bone mineral density during long-term prophylaxis with heparin in pregnancy.

    abstract：OBJECTIVE:We studied the effect of long-term heparin treatment on bone mass during pregnancy. STUDY DESIGN:Thromboprophylaxis with heparin was given to 39 women during pregnancy for a mean of 28 weeks and for an average of 6 weeks post partum. Bone mineral density measured with single-photon absorptiometry of the dist...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(94)70149-0

    authors： Dahlman TC,Sjöberg HE,Ringertz H

    更新日期：1994-05-01 00:00:00

  • Post-cesarean section splenic rupture.

    abstract：:We report a case of splenic rupture after cesarean delivery for abruptio placentae. The diagnosis was not suspected until a laparotomy was performed. Diagnosis and management were complicated by disseminated intravascular coagulation and renal failure. The importance of early diagnosis and management modalities are di...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(95)90199-x

    authors： Kaluarachchi A,Krishnamurthy S

    更新日期：1995-07-01 00:00:00

  • Comparison of conventional 2D ultrasound to magnetic resonance imaging for prenatal estimation of birthweight in twin pregnancy.

    abstract：BACKGROUND:During prenatal follow-up of twin pregnancies, accurate identification of birthweight and birthweight discordance is important to identify the high-risk group and plan perinatal care. Unfortunately, prenatal evaluation of birthweight discordance by 2-dimensional ultrasound has been far from optimal. OBJECTI...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2017.10.009

    authors： Kadji C,Bevilacqua E,Hurtado I,Carlin A,Cannie MM,Jani JC

    更新日期：2018-01-01 00:00:00

  • Inhibition of fetal membrane prostaglandin production by prolactin: relative importance in the initiation of labor.

    abstract：:Production of a biologically active prolactin by human decidual tissue and its influence on the permeability of amniochorion to water suggests a functional relationship between the polypeptide and fetal membrane metabolism. Under in vitro circumstances, we used ovine prolactin and the Ussing chamber technique to deter...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(85)90375-8

    authors： Tyson JE,McCoshen JA,Dubin NH

    更新日期：1985-04-15 00:00:00

  • The cardiorespiratory effects of perfluorochemicals on acute carbon monoxide poisoning in the pregnant ewe.

    abstract：:Studies in nonpregnant animal models of carbon monoxide poisoning have demonstrated the protective effect of perfluorochemicals. Anesthetized pregnant ewes were exposed to carbon monoxide. After symptoms of toxicity were demonstrated, group 1 animals were respired with room air. Group 2 animals respired room air and w...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(86)90364-9

    authors： Baker VV,Egley CC,Cefalo RC,Proctor H

    更新日期：1986-11-01 00:00:00

  • The procoagulant activity of red blood cells from patients with severe preeclampsia.

    abstract：OBJECTIVE:Our purpose was to determine whether red blood cells from patients with severe preeclampsia may exhibit increased membrane exposure of procoagulant phospholipids (i.e., phosphatidylserine), which may initiate intravascular clotting and platelet activation. STUDY DESIGN:The study group comprised 28 women: 9 w...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(97)70100-5

    authors： Grisaru D,Zwang E,Peyser MR,Lessing JB,Eldor A

    更新日期：1997-12-01 00:00:00

  • Atrial natriuretic factor: the effects of pregnancy and a high-salt diet on atrial levels.

    abstract：:The chronic and relatively acute changes in blood volume that occur during pregnancy and post partum may be associated with alterations in the content of atrial natriuretic factor in the atria. We measured the concentration of atrial natriuretic factor in the right and left atria of virgin, pregnant, and postpartum Sp...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(89)90937-x

    authors： Castro LC,Arora CP,Davis JL,Hobel CJ,Parvez H

    更新日期：1989-12-01 00:00:00

  • Assessment of diagnostic aspiration curettage as an outpatient procedure.

    abstract：:Aspiration curettage proved acceptable to patients and medical staff when incorporated into a busy outpatient practice. The diagnostic reliability of curettings obtained was shown to be 93.5 per cent accurate. In all patients where mucus only is obtained, where symptoms persist or recur, or when aspiration curettage i...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(75)90622-5

    authors： Liu DT,Melville HA,Measday B,Melcher D

    更新日期：1975-05-01 00:00:00

  • Incorporating endovaginal ultrasonography into the overall gynecologic examination.

    abstract：:Previously endovaginal ultrasonography was considered an adjunct for use in full-service ultrasound facilities by subspecialists only. The technique, however, has tremendous application for use by the clinician in the examination room for patients at bimanual examination. This is because the procedure is meant to be p...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(90)90971-9

    authors： Goldstein SR

    更新日期：1990-03-01 00:00:00

  • Rh isoimmunization: a 24 year experience at Duke University Medical Center.

    abstract：:A retrospective analysis was made of Rh-sensitized patients delivered of their babies at Duke University Medical Center during a 24 year period. Records of 202 obstetric patients representing 280 sensitized pregnancies from a pool of 39,910 deliveries were analyzed for past obstetric history, blood group information, ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(81)90083-1

    authors： Gall SA,Miller JM Jr

    更新日期：1981-08-15 00:00:00

  • The cavitational ultrasonic surgical aspirator for cytoreduction in advanced ovarian cancer.

    abstract：OBJECTIVE:The cavitational ultrasonic surgical aspirator is a newer surgical instrument that has been shown to be effective in tumor resection. The purpose of this study was to evaluate its usefulness for cytoreduction of advanced ovarian cancer. STUDY DESIGN:Over a 24-month period patients with advanced ovarian cance...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(92)91345-b

    authors： Rose PG

    更新日期：1992-03-01 00:00:00

  • Predictors of adverse events among pregnant smokers exposed in a nicotine replacement therapy trial.

    abstract：OBJECTIVE:The purpose of this study was to determine the contribution of randomization to nicotine replacement therapy (NRT), sociodemographic and psychosocial factors, and pregnancy and medical history to serious perinatal adverse events among pregnant smokers. STUDY DESIGN:We performed a retrospective review of all ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.ajog.2009.06.006

    authors： Swamy GK,Roelands JJ,Peterson BL,Fish LJ,Oncken CA,Pletsch PK,Myers ER,Whitecar PW,Pollak KI

    更新日期：2009-10-01 00:00:00

  • Maternal benefit of corticosteroid therapy in patients with HELLP (hemolysis, elevated liver enzymes, and low platelet count) syndrome: impact on the rate of regional anesthesia.

    abstract：OBJECTIVE:Our purpose was to assess the impact of glucocorticoid administration on the rate of regional anesthesia in women with hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome. STUDY DESIGN:Maternal records of pregnancies with HELLP syndrome managed between April 1994 and December 1999 were...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2002.121074

    authors： O'Brien JM,Shumate SA,Satchwell SL,Milligan DA,Barton JR

    更新日期：2002-03-01 00:00:00

  • Abruptio placentae risk and genetic variations in mitochondrial biogenesis and oxidative phosphorylation: replication of a candidate gene association study.

    abstract：BACKGROUND:Abruptio placentae is a complex multifactorial disease that is associated with maternal and neonatal death and morbidity. Abruptio placentae's high recurrence rate, high prevalence of heritable thrombophilia among women with abruptio placentae, and aggregation of cases in families of women with the disease s...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2018.08.042

    authors： Workalemahu T,Enquobahrie DA,Gelaye B,Thornton TA,Tekola-Ayele F,Sanchez SE,Garcia PJ,Palomino HG,Hajat A,Romero R,Ananth CV,Williams MA

    更新日期：2018-12-01 00:00:00

  • No evidence for lipid peroxidation in severe preeclampsia.

    abstract：OBJECTIVE:This study was undertaken to address the role of oxidative stress in preeclampsia. STUDY DESIGN:We measured urinary 8,12-iso-iPF(2alpha)-VI, a chemically stable, free-radical catalyzed product, in a case control study of severe preeclampsia nested within the trial of Calcium for Preeclampsia Prevention. Case...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2001.116754

    authors： Regan CL,Levine RJ,Baird DD,Ewell MG,Martz KL,Sibai BM,Rokach J,Lawson JA,Fitzgerald GA

    更新日期：2001-09-01 00:00:00

  • Temporal relationships of neuropathologic conditions caused by perinatal asphyxia.

    abstract：:The neuropathologic conditions in 120 perinatal deaths attributed to fetal or newborn asphyxia were examined. Central nervous system necrosis was present in 16 of these deaths. The approximate time of asphyxial insult was established by determining the duration of the process, based on the findings of neuronal necrosi...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/s0002-9378(89)80040-7

    authors： Low JA,Robertson DM,Simpson LL

    更新日期：1989-03-01 00:00:00

  • The Pregnancy and Influenza Project: design of an observational case-cohort study to evaluate influenza burden and vaccine effectiveness among pregnant women and their infants.

    abstract：:The US Centers for Disease Control and Prevention is conducting an observational study of 300-500 women infected with influenza during pregnancy. Women are being recruited from members of the Kaiser Permanente health plan in 2 metropolitan areas before and during the 2010 through 2011 influenza season either following...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2011.01.006

    authors： Thompson M,Williams J,Naleway A,Li DK,Chu S,Bozeman S,Hill HA,Cragan J,Shay DK,Pregnancy and Influenza Project Workgroup.

    更新日期：2011-06-01 00:00:00

  • Beneficial impact of term labor: nonenzymatic antioxidant reserve in the human fetus.

    abstract：OBJECTIVE:Oxidative stress occurs when the production of damaging free radicals and other oxidative molecules exceeds the capacity of the body's antioxidant defenses. Oxidative stress is implicated in diseases that are associated with prematurity (such as retinopathy, cerebral palsy, intraventricular hemorrhage, and ne...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2003.357

    authors： Buhimschi IA,Buhimschi CS,Pupkin M,Weiner CP

    更新日期：2003-07-01 00:00:00

  • Iatrogenic prematurity due to elective termination of the uncomplicated pregnancy: a major perinatal health care problem.

    abstract：:In a series of 1,000 newborn infants referred to a regional neonatal center, 32 iatrogenically preterm infants were identified. All had been delivered following elective termination of uncomplicated, apparently term pregnancies, without prior documentation of fetal lung maturity or ultrasonic determination of fetal bi...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(78)90717-2

    authors： Flaksman RJ,Vollman JH,Benfield DG

    更新日期：1978-12-15 00:00:00

  • The prevention of postoperative pelvic adhesions: an animal study comparing barrier methods with dextran 70.

    abstract：:There are two major approaches to the prophylaxis for adhesions: chemical methods (e.g., dextran) and barrier methods. Theoretically, dextran prevents the formation of adhesions by a surface-coating or hydroflotation effect, whereas the barrier methods either prevent the formation of or mask adhesions by covering and ...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(82)90018-7

    authors： Soules MR,Dennis L,Bosarge A,Moore DE

    更新日期：1982-08-01 00:00:00

  • Cervicovaginal microflora and pregnancy outcome: results of a double-blind, placebo-controlled trial of erythromycin treatment.

    abstract：:Available information suggests that some instances of preterm birth or premature rupture of membranes are associated with clinically unrecognized infection and inflammation of the lower uterine segment, decidua, and fetal membranes. Various cervicovaginal microorganisms have been recovered from these sites. Many of th...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 临床试验,杂志文章

    doi：10.1016/0002-9378(90)90632-h

    authors： McGregor JA,French JI,Richter R,Vuchetich M,Bachus V,Seo K,Hillier S,Judson FN,McFee J,Schoonmaker J

    更新日期：1990-11-01 00:00:00

  • Cytologically diagnosed Gardnerella vaginalis infection and cervical (pre)neoplasia as established in population-based cervical screening.

    abstract：OBJECTIVE:Cervical inflammation has been proposed as a cofactor in the development of cervical cancer. The purpose of this study was to document the prevalence of cervical (pre)neoplastic changes in asymptomatic women with a cytologically diagnosed Gardnerella vaginalis infection. STUDY DESIGN:Data were collected from...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2008.04.036

    authors： Klomp JM,Boon ME,Van Haaften M,Heintz AP

    更新日期：2008-11-01 00:00:00

  • Excision of an epidermal inclusion cyst: Correction of a long-term complication of female genital circumcision.

    abstract：:Epidermal inclusion cysts are a late complication of female genital circumcision, which is a practice that affects 125 million women primarily from Africa and the Middle East. A 30-year-old woman, gravida 4, para 1, presented to our clinic with an 8-year history of a slowly enlarging periclitoral mass. The patient had...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2016.03.026

    authors： Dun EC,Ackerman C,Cutler A,Lakhi NA

    更新日期：2016-06-01 00:00:00

  • Epidemiology of low-grade serous ovarian cancer.

    abstract：OBJECTIVE:The objective of the study was to determine whether the epidemiology of low-grade ovarian serous cancers is distinct from that of high-grade ovarian serous cancers. STUDY DESIGN:The National Cancer Institute's Surveillance Epidemiology and End Results (SEER) program reports incidence, and survival, data from...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2008.01.035

    authors： Plaxe SC

    更新日期：2008-04-01 00:00:00

  • Is Burch colposuspension ever cost-effective compared with tension-free vaginal tape for stress incontinence?

    abstract：OBJECTIVE:This study was undertaken to evaluate the cost-effectiveness of Burch colposuspension compared with tension-free vaginal tape. STUDY DESIGN:A Markov decision model was developed to compare costs (2005 US dollars) and effectiveness (quality-adjusted life years) of Burch and tension-free vaginal tape for stres...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/j.ajog.2007.02.039

    authors： Wu JM,Visco AG,Weidner AC,Myers ER

    更新日期：2007-07-01 00:00:00

  • Coronavirus Disease 2019 (COVID-19) and pregnancy: what obstetricians need to know.

    abstract：:Coronavirus disease 2019 is an emerging disease with a rapid increase in cases and deaths since its first identification in Wuhan, China, in December 2019. Limited data are available about coronavirus disease 2019 during pregnancy; however, information on illnesses associated with other highly pathogenic coronaviruses...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章,评审

    doi：10.1016/j.ajog.2020.02.017

    authors： Rasmussen SA,Smulian JC,Lednicky JA,Wen TS,Jamieson DJ

    更新日期：2020-05-01 00:00:00

  • Prenatal diagnosis of symptomatic congenital cytomegalovirus infection.

    abstract：OBJECTIVE:The aim of this study was to evaluate whether the amniotic viral load of mothers with primary cytomegalovirus infection correlate with fetal or neonatal outcomes. STUDY DESIGN:Sixty-eight of 138 pregnant women with primary infection defined by immunoglobulin G seroconversion or the presence of immunoglobulin...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1067/mob.2000.106347

    authors： Guerra B,Lazzarotto T,Quarta S,Lanari M,Bovicelli L,Nicolosi A,Landini MP

    更新日期：2000-08-01 00:00:00

  • Lymphokine production during term human pregnancy: differences between peripheral leukocytes and decidual cells.

    abstract：:Although the fetus is considered to be an "allograft" there is little information concerning the role of lymphokines in human pregnancy. Lymphokines are polypeptides secreted by stimulated lymphocytes that direct the immune response by enabling immune effector cells to communicate with each other. To characterize lymp...

    journal_title：American journal of obstetrics and gynecology

    pub_type： 杂志文章

    doi：10.1016/0002-9378(90)90769-4

    authors： Dudley DJ,Mitchell MD,Creighton K,Branch DW

    更新日期：1990-12-01 00:00:00