当前位置： SCI文献检索 > AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY期刊下所有文献 > Serologic response to the E4, E6, and E7 proteins of human papillomavirus type 16 in pregnant women.

Serologic response to the E4, E6, and E7 proteins of human papillomavirus type 16 in pregnant women.

Abstract：

OBJECTIVE:In a seroepidemiologic study the effects of pregnancy and other factors on humoral response to human papillomavirus type 16 infection were examined. STUDY DESIGN:Multiple serum samples were taken at 3-month intervals for 15 months from 77 pregnant and 85 nonpregnant women. Serologic response to human papillomavirus type 16 proteins was analyzed with a peptide-based enzyme-linked immunosorbent assay. RESULTS:Seroreactivity was higher in nonpregnant women than in pregnant women, suggesting a reduced humoral immune response against human papillomavirus infections during pregnancy. Among the pregnant women a twofold to threefold decrease in mean reactivity in the E4 protein-based assay was detected between early gestation and delivery. The presence of human papillomavirus type 16 or 18 deoxyribonucleic acid was significantly associated with reactivity to the E6 protein (p = 0.0005) and the E4 protein (p = 0.06). Reactivity to the E4 protein also correlated with an abnormal Papanicolaou smear. CONCLUSIONS:The observation of changes in humoral response to genital human papillomavirus infections during pregnancy warrants further investigation with highly seroreactive assays.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Sethi S,Müller M,Schneider A,Blettner M,Smith E,Turek L,Wahrendorf J,Gissmann L,Chang-Claude J

doi

10.1016/s0002-9378(98)80026-4

subject

Has Abstract

pub_date

1998-02-01 00:00:00

pages

360-4

issue

2

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(98)80026-4

journal_volume

178

pub_type

杂志文章

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