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Neurokinin B peptide serum levels are higher in normotensive pregnant women than in preeclamptic pregnant women.

Abstract：

OBJECTIVES:The purpose of this study was to examine neurokinin B levels in serum from preeclamptic and normotensive and to investigate the role of neurokinin B in preeclampsia. STUDY DESIGN:Peripheral and uterine venous blood neurokinin B levels were measured in 14 normotensive and 8 preeclamptic pregnant women by radioimmunoassay. RESULTS:Neurokinin B levels in normotensive women were 4.91 +/- 2.67 nmol/L in peripheral and 5.59 +/- 2.06 nmol/L in uterine blood. In pregnant women with preeclampsia, neurokinin B levels were 2.79 +/- 1.68 nmol/L and 3.20 +/- 1.55 nmol/L, respectively. Neurokinin B levels were significantly higher in normotensive women (P=.032 in peripheral and P=.006 in uterine blood). CONCLUSIONS:Neurokinin B serum levels were higher in normotensive women. Higher neurokinin B concentrations in normotensive pregnant women may be due to the advanced gestational age and/or the result of a negative interaction of other vasoactive substances. The role of neurokinin B in preeclampsia remains to be determined.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Schlembach D,Scalera F,Fischer T,Marx SG,Beinder E,Garfield RE

doi

10.1067/s0002-9378(03)00775-0

subject

Has Abstract

pub_date

2003-11-01 00:00:00

pages

1418-22

issue

5

eissn

0002-9378

issn

1097-6868

pii

S0002937803007750

journal_volume

189

pub_type

杂志文章

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