Effects of maternal cigarette smoking on placental volume and vascularization measured by 3-dimensional power Doppler ultrasonography at 11+0 to 13+6 weeks of gestation.

Abstract:

OBJECTIVE:We sought to establish the effect of maternal smoking on placental volume and vascularization in early gestation. STUDY DESIGN:Three-dimensional power Doppler ultrasonography of the placenta was performed at 11+0 to 13+6 weeks in 80 pregnancies categorized according to cigarette consumption: group A never smoked, B smoking < 10 cigarettes/day, C smoking 10-20 cigarettes/day, and D smoking > 20 cigarettes/day. Using a standardized setting, placental volume and vascularization index (VI), flow index (FI), and vascularization flow index (VFI) were calculated. RESULTS:No differences were found in placental volume among groups. In groups C and D lower values were found for VI (group C: t = 4.52, P = .0002; group D: t = 3.72, P = .0014), FI (group C: t = 5.06, P = .0001; group D: t = 4.59, P = .0002), and VFI (group C: t = 3.49, P = .0024; group D: t = 2.88, P = .0095). Placental vascular indices were significantly related to birthweight (VI r = 0.563, FI r = 0.580, VFI r = 0.601; P < .001). CONCLUSION:Maternal smoking is associated with altered 3-dimensional placental Doppler indices and these changes are related to birth weight.

journal_name

Am J Obstet Gynecol

authors

Rizzo G,Capponi A,Pietrolucci ME,Arduini D

doi

10.1016/j.ajog.2008.10.041

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

415.e1-5

issue

4

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(08)02053-X

journal_volume

200

pub_type

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