Selective estrogen receptor modulators: Women's panacea for the next millennium?

Abstract:

:The purpose of this review is to assimilate relevant experimental and clinical information available on selective estrogen receptor modulators with respect to their potential use as agents to improve women's health in the postmenopausal years. In addition, the mechanisms of action of these drugs are outlined. Selective estrogen receptor modulators represent an exciting group of antiestrogens that possess agonist action on bone, lipids, and lipoproteins and antagonistic action in the endometrium and breast. Thus in theory these drugs may preserve bone density and reduce the risk of osteoporotic fracture and coronary heart disease at the same time that they lower the incidences of breast and endometrial neoplasms. Short-term data with the use of raloxifene suggest that bone is preserved and lipid profiles are less atherogenic. Long-term studies are needed to determine whether raloxifene or other selective estrogen receptor modulators are associated with any decrease in the risk of breast or endometrial cancer.

journal_name

Am J Obstet Gynecol

authors

Spencer CP,Morris EP,Rymer JM

doi

10.1016/s0002-9378(99)70285-1

subject

Has Abstract

pub_date

1999-03-01 00:00:00

pages

763-70

issue

3 Pt 1

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(99)70285-1

journal_volume

180

pub_type

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