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Collagen scaffold: a treatment for simulated maternal birth injury in the rat model.

Abstract：

OBJECTIVE:We sought to determine the impact of a collagen scaffold on the healing response after simulated birth injury in a rodent model. STUDY DESIGN:A total of 52 virgin animals were divided into the following groups: control (n = 18), injured untreated (n = 18), and injured treated with porcine small intestinal submucosa (SIS) (n = 16). Histopathology, immunofluorescence of collagens, and vaginal mechanical properties were used to assess the impact of injury and the subsequent healing response. RESULTS:Collagen I/V decreased by 44% after birth injury relative to the controls (P = .001). Birth injury resulted in inferior mechanical properties of the vagina with a decrease of 38% in the tangent modulus and 44% in the tensile strength. SIS improved the collagen I/V and I/III ratios by 28% and 46%, respectively, paralleling the trend in the mechanical properties. CONCLUSION:Simulated birth injury negatively affected vaginal biochemical and biomechanical properties long term. SIS treatment mitigated the impact of birth injury by enhancing tissue quality.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Alperin M,Feola A,Meyn L,Duerr R,Abramowitch S,Moalli P

doi

10.1016/j.ajog.2010.04.003

subject

Has Abstract

pub_date

2010-06-01 00:00:00

pages

589.e1-8

issue

6

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(10)00416-3

journal_volume

202

pub_type

杂志文章

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