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Cardiovascular risk factors in women who had hypertensive disorders late in pregnancy: a cohort study.

Abstract：

OBJECTIVE:The purpose of this study was to determine cardiovascular risk factors in women with a history of hypertensive pregnancy disorders at term (HTP) 2.5 years after pregnancy. STUDY DESIGN:In a multicenter cohort study in The Netherlands from June 2008 through November 2010, cardiovascular risk factors were compared between women with a history of HTP (HTP cohort, n = 306) and women with a history of normotensive pregnancies at term (NTP cohort, n = 99). HTP women had participated in a randomized, longitudinal trial assessing the effectiveness of induction of labor in women with hypertensive pregnancy disorders at term. All women were assessed 2.5 years after pregnancy for blood pressure, anthropometrics, glucose, glycosylated hemoglobin, insulin, homeostatic model assessment score, total cholesterol, high-density lipoprotein cholesterol, triglycerides, high-sensitivity C-reactive protein, and microalbumin and metabolic syndrome. RESULTS:After a mean follow-up period of 2.5 years, hypertension (HTP, 34%; NTP, 1%; P < .001) and metabolic syndrome (HTP, 25%; NTP, 5%; P < .001) were more prevalent in HTP women compared with NTP women. HTP women had significantly higher systolic and diastolic blood pressure, higher body mass index, and higher waist circumference. Glucose, glycosylated hemoglobin, insulin, homeostatic model assessment score, total cholesterol, triglycerides, and high-sensitivity C-reactive protein levels were significantly higher and high-density lipoprotein cholesterol was significantly lower in HTP women. CONCLUSION:In women with a history of HTP, hypertension and metabolic syndrome are more common, and they have higher levels of biochemical cardiovascular risk factors 2.5 years after pregnancy.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Hermes W,Franx A,van Pampus MG,Bloemenkamp KW,Bots ML,van der Post JA,Porath M,Ponjee GA,Tamsma JT,Mol BW,de Groot CJ

doi

10.1016/j.ajog.2013.02.016

subject

Has Abstract

pub_date

2013-06-01 00:00:00

pages

474.e1-8

issue

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(13)00157-9

journal_volume

208

pub_type

杂志文章,多中心研究,随机对照试验

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Cardiovascular risk factors in women who had hypertensive disorders late in pregnancy: a cohort study.