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Postsurgical medical treatment of advanced endometriosis: results of a randomized clinical trial.

Abstract：

OBJECTIVE:Our purpose was to investigate the efficacy of postsurgical treatment with nafarelin in women with advanced endometriosis. STUDY DESIGN:Eligible for trial were women < or = 38 years old with unexplained infertility with or without chronic pelvic pain and stage III or IV endometriosis according to the American Fertility Society, revised, classification who underwent laparotomy as first surgical treatment for debulking or radical surgery of endometriotic lesions. Patients were assigned according to a randomization list to nasal nafarelin, 400 micrograms/day (36 subjects) or placebo nasal spray (39 subjects) for 3 months. Pelvic pain was assessed before first surgery and at the 12-month follow-up visit in women with pelvic pain by means of a multidimensional score system and a 10-point linear pain scale. RESULTS:No marked differences in pain scores emerged among women allocated to different treatments. The mean reduction of the multidimensional score was 3.6 and 4.0, respectively, in women allocated to nafarelin and placebo and of the 10-point linear scale scores was 7.0 and 6.9. These differences were not statistically significant. Within 1 year from randomization, of the 36 women allocated to nafarelin and the 39 allocated to placebo, seven (19%) and seven (18%), respectively, became pregnant. CONCLUSION:This study suggests that medical treatment with nafarelin does not markedly improve pelvic pain and short-term reproductive prognosis in women with stages III and IV endometriosis.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Parazzini F,Fedele L,Busacca M,Falsetti L,Pellegrini S,Venturini PL,Stella M

doi

10.1016/0002-9378(94)90133-3

subject

Has Abstract

pub_date

1994-11-01 00:00:00

pages

1205-7

issue

5

eissn

0002-9378

issn

1097-6868

pii

0002-9378(94)90133-3

journal_volume

171

pub_type

临床试验,杂志文章,随机对照试验

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