Eszopiclone improves insomnia and depressive and anxious symptoms in perimenopausal and postmenopausal women with hot flashes: a randomized, double-blinded, placebo-controlled crossover trial.

Abstract:

OBJECTIVE:Menopause-associated insomnia is commonly associated with other symptoms (hot flashes, depression, anxiety). Given frequent symptom cooccurrence, therapies targeting sleep may provide an important approach to treatment during midlife. STUDY DESIGN:Peri/postmenopausal women (40-65 years old) with sleep-onset and/or sleep-maintenance insomnia cooccurring with hot flashes and depressive and/or anxiety symptoms were randomized to eszopiclone 3 mg orally or placebo in a double-blinded, crossover 11 week trial. Changes in the Insomnia Severity Index (ISI) scale and secondary outcomes (diary-based sleep parameters, depression/anxiety, hot flashes, quality of life) were analyzed using repeated-measure linear models. RESULTS:Of 59 women, 46 (78%) completed the study. Eszopiclone reduced ISI scores by 8.7 + or - 1.4 more points than placebo (P < .0001). Eszopiclone improved (P < .05) all sleep parameters, depressive symptoms, anxiety symptoms, quality of life, and nighttime but not daytime hot flashes. CONCLUSION:Eszopiclone treats insomnia and cooccurring menopause-related symptoms. Our results provide evidence that hypnotic therapies may improve multiple domains of well-being during midlife.

journal_name

Am J Obstet Gynecol

authors

Joffe H,Petrillo L,Viguera A,Koukopoulos A,Silver-Heilman K,Farrell A,Yu G,Silver M,Cohen LS

doi

10.1016/j.ajog.2009.10.868

subject

Has Abstract

pub_date

2010-02-01 00:00:00

pages

171.e1-171.e11

issue

2

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(09)02006-7

journal_volume

202

pub_type

杂志文章,随机对照试验
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    authors: Estellés A,Gilabert J,España F,Aznar J,Galbis M

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    更新日期:1981-07-01 00:00:00

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    更新日期:1992-11-01 00:00:00

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    更新日期:2015-07-01 00:00:00

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    更新日期:1996-08-01 00:00:00

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    pub_type: 杂志文章,随机对照试验

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    更新日期:2000-10-01 00:00:00

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    pub_type: 杂志文章,评审

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