Prenatal sex determination by fluorescent staining of the cervical smear for the presence of a Y chromosome: an evaluation.

Abstract:

:If the parents do not want to take the 50% chance that a male fetus will be involved with an x-linked disease, it is desirable to predict fetal sex early enough to safely terminate pregnancy. Slides obtained from midcervical smears of 20 consecutive patients at different stages of gestation were stained with .5% aqueous solution of quinacrine hydrochloride then dipped 3 times in a buffer with pH of 5.5 and mounted wet. On each slide 100 cells were studied with fluorescent light. In none was the characteristic fluorescent y-body seen. As there was no follow-up, an additional 18 patients were similarly studied. 7 delivered male infants in spite of the absence of a y-body on cervical smears. It is concluded that this technique is not satisfactory for prenatal sex determination.

journal_name

Am J Obstet Gynecol

authors

Goldstein AI,Lukesh RC,Ketchum M

doi

10.1016/0002-9378(73)90541-3

subject

Has Abstract

pub_date

1973-03-15 00:00:00

pages

866

issue

6

eissn

0002-9378

issn

1097-6868

pii

0002-9378(73)90541-3

journal_volume

115

pub_type

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