Placental prostaglandin levels in pre-eclampsia.

Abstract:

:Pre-eclampsia is characterized by uteroplacental ischemia. Prostaglandins can alter systemic blood pressure as well as regulate blood flow to the fetoplacental unit. In the present study, levels of prostaglandin E were significantly decreased in placental tissue from pre-eclamptic patients. Prostaglandin F, a potent vasoconstrictor, was markedly elevated. These observations indicate that altered placental metabolism of prostaglandins is an important factor in the pathophysiology of pre-eclampsia.

journal_name

Am J Obstet Gynecol

authors

Demers LM,Gabbe SG

doi

10.1016/0002-9378(76)90478-6

subject

Has Abstract

pub_date

1976-09-01 00:00:00

pages

137-9

issue

1

eissn

0002-9378

issn

1097-6868

pii

0002-9378(76)90478-6

journal_volume

126

pub_type

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