New approaches for the treatment of bacterial vaginosis.

Abstract:

OBJECTIVE:Review alternative approaches to oral metronidazole for the treatment of bacterial vaginosis. STUDY DESIGN:Assessment of clinical trials on the treatment of bacterial vaginosis with regimens other than 5 to 7 days of metronidazole. RESULTS:Single-dose metronidazole, 2 gm orally, is as effective as 5- to 7-day courses of oral metronidazole, with cure rates in the 80% to 90% range. Oral clindamycin results in more than a 90% clinical cure rate. Intravaginal clindamycin cream 2% and intravaginal metronidazole gel 0.75% are associated with clinical cure rates similar to those for oral metronidazole. CONCLUSIONS:Single-dose metronidazole, oral clindamycin, intravaginal clindamycin cream, and intravaginal metronidazole gel are effective and safe alternatives to a 5- to 7-day course of oral metronidazole for the treatment of bacterial vaginosis.

journal_name

Am J Obstet Gynecol

authors

Sweet RL

doi

10.1016/0002-9378(93)90346-k

subject

Has Abstract

pub_date

1993-08-01 00:00:00

pages

479-82

issue

2 Pt 2

eissn

0002-9378

issn

1097-6868

pii

0002-9378(93)90346-K

journal_volume

169

pub_type

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