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Intravaginal metronidazole gel versus metronidazole plus nystatin ovules for bacterial vaginosis: a randomized controlled trial.

Abstract：

OBJECTIVE:We compared metronidazole 0.75% gel (containing 37.5 mg metronidazole per dose) with ovules containing metronidazole 500 mg and nystatin 100,000 U, for intravaginal treatment of bacterial vaginosis (BV). STUDY DESIGN:In a single-blinded trial, symptomatic women with BV by both Amsel and Nugent criteria were randomly assigned to gel or ovules, once nightly for 5 nights, and asked to return 3 times after treatment. Analyses were intent-to-treat. RESULTS:Of 151 women with BV by both criteria at enrollment, 138 (91%) returned at least once. Product limit estimates for persistence or recurrence of BV at 14, 42, and 104 days were 20% (95% CI 10%-29%), 38% (95% CI 25%-48%), and 52% (95% CI 37%-63%) after gel treatment, and 4% (95% CI 0%-9%), 17% (95% CI 7%-26%), and 33% (95% CI 21%-46%) after ovule treatment ( P = .01). Among women without BV at first follow-up, subsequent intercourse without condoms independently predicted subsequent recurrence ( P

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Sanchez S,Garcia PJ,Thomas KK,Catlin M,Holmes KK

doi

10.1016/j.ajog.2004.06.089

subject

Has Abstract

pub_date

2004-12-01 00:00:00

pages

1898-906

issue

6

eissn

0002-9378

issn

1097-6868

pii

S0002937804007124

journal_volume

191

pub_type

临床试验,杂志文章,随机对照试验

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