Vitamin D (soltriol), light, and reproduction.

Abstract:

:Evidence from autoradiographic studies with 1,25(OH)2-vitamin D3 (vitamin D, soltriol) labeled with tritium and from the literature indicates that the steroid hormone soltriol regulates and modulates reproductive processes in the female, as it does in the male. Nuclear receptors for soltriol have been discovered in the uterus, oviduct, ovary, mammary gland, placenta, and fetal membranes, as well as in the pituitary and hypothalamus. Soltriol is recognized as a transducer and hormonal messenger of sunlight, acting as a somatotropic activator and modulator of vital processes for the seasonal and estival adaptation of growth, development, and procreation. Its influence on calcium equilibrium is just one of its many functions to serve this goal. This article reviews experimental, clinical, and epidemiologic evidence that suggests the involvement of soltriol in the control of reproductive processes, noting its importance for the onset of puberty, fertility, pregnancy, lactation, and probably sexual behavior. Cooperative actions between soltriol and other steroid hormones, especially estradiol, are pointed out.

journal_name

Am J Obstet Gynecol

authors

Stumpf WE,Denny ME

doi

10.1016/0002-9378(89)90699-6

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

1375-84

issue

5

eissn

0002-9378

issn

1097-6868

pii

0002-9378(89)90699-6

journal_volume

161

pub_type

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