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Amniotic fluid induces platelet-neutrophil aggregation and neutrophil activation.

Abstract：

OBJECTIVE:Amniotic fluid embolism syndrome is a fatal disease in pregnant women. The exact role of platelets and neutrophils in amniotic fluid embolism syndrome is not clear. We examined whether amniotic fluid could affect platelet-neutrophil aggregation and activation and the possible mechanisms. STUDY DESIGN:Blood samples from the pregnant women were pretreated ex vivo with their own amniotic fluid. Flow cytometry was used to measure platelet-neutrophil aggregation and activation. Neutrophil-mediated activity of p38 mitogen-activated protein kinase and extracellular signal-regulated protein kinases 1 and 2 was analyzed by Western blotting. RESULTS:Amniotic fluid significantly induced platelet-neutrophil aggregation, neutrophil CD11b expression, and reactive oxygen species production. Amniotic fluid induced minimal platelet P-selectin expression. The increase of intracellular calcium level of neutrophils and the activity of p38 mitogen-activated protein kinase were enhanced by amniotic fluid stimulation. CONCLUSION:Amniotic fluid was able to induce neutrophil activation and platelet-neutrophil aggregation with minimal effect on platelet activation. These findings may provide a new insight in the understanding of the pathophysiologic condition of amniotic fluid embolism syndrome.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Chen KB,Chang SS,Tseng YL,Chiu TH,Liao CC,Ho M,Huang GS,Li CY

doi

10.1016/j.ajog.2013.01.012

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

318.e1-7

issue

4

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(13)00048-3

journal_volume

208

pub_type

杂志文章

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