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Gap junction currents in cultured muscle cells from human myometrium.

Abstract：

OBJECTIVE:The electrophysiologic properties of gap junctions between human myometrial smooth muscle cells were studied. STUDY DESIGN:Double whole-cell patch clamp recordings were made on pairs of cells from primary cultures of myometrial cells from women undergoing cesarean section. Macroscopic gap junction currents were measured as the change in current in a cell held at a constant voltage while the other member of a pair was subjected to a test pulse of voltage. The blockade by halothane was examined. RESULTS:Mean junctional conductance between pairs of cells was 23 +/- 14 nanosiemens (n = 57). Instantaneous gap junction conductance was constant as a function of transjunctional voltage. For transjunctional voltages of < or = 50 mV, currents were constant during a 5-second test pulse. For larger voltages, however, the currents showed a time-dependent decay. The currents were blocked completely and reversibly with 3.5 mmol/L halothane. Single-channel conductances of 60 picosiemens and 15 picosiemens were observed. CONCLUSION:This first study of gap junction currents in human myometrial cells confirms that connexin43 is the major functional constituent. Functional studies of myometrial gap junction channels may suggest new strategies for controlling uterine contractility.

journal_name

Am J Obstet Gynecol

journal_title

American journal of obstetrics and gynecology

authors

Miyoshi H,Boyle MB,MacKay LB,Garfield RE

doi

10.1016/s0002-9378(98)70443-0

subject

Has Abstract

pub_date

1998-03-01 00:00:00

pages

588-93

issue

3

eissn

0002-9378

issn

1097-6868

pii

S0002-9378(98)70443-0

journal_volume

178

pub_type

杂志文章

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